Overview
- Provides a blueprint on how circulating tumor cells can be employed in the future
- Features authors from diverse backgrounds in biology, biochemistry, and medical oncology?
- Delivers a “one-stop” text that provides fundamental knowledge on each of the sub-topics of circulating tumor cell biology
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Cancer Research (CUCR)
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Table of contents (16 chapters)
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Front Matter
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Technologies for CTC Identification
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Front Matter
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CTC Analysis
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Front Matter
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Keywords
About this book
CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive “liquid biopsy” procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development. In recent years there has been rapid growth and worldwide developments on CTCs, which span both the basic sciences and biomedical engineering fields.
Reviews
“The book will prove to be a useful resource for graduate students and established researchers with an interest in this field. It can provide a definitive source for the much-needed but often neglected theoretical framework for hospitals and laboratories desirous of establishing a CTC assay, in addition to providing practical tips. It should be included in the collection of libraries that cater to oncology clinicians, laboratory personnel as well as basic researchers.” (Sudeep Gupta, The National Medical Journal of India, Vol. 30 (1), January-February, 2017)
“The book is divided into four chapters that beyond of methodological issues summarize comprehensive information on biological nature, genesis, molecular characteristics, alterations, behaviour and clinical utility of CTCs. … ‘Circulating tumour cells’ brings us comprehensive review of current state-of-art in methodological approaches, clinical application and future perspectives of CTCs research.” (Bozena Smolkova, Neoplasma, Vol. 63 (5), 2016)
Editors and Affiliations
About the editors
Miller School of Medicine and the University of Miami Health System, and
Chief of Pathology, Jackson Memorial Hospital. As well, he is Director, the University of Miami Biomedical Nanoscience Institute. Dr. Cote, the recipient of more than $35 million in peer reviewed grant support, holds numerous patents for cancer-related and nanoscale technologies. Dr. Cote also serves as a member and advisor to numerous national and international study groups, cancer programs, and societies—including the National Cancer Institute. The editor and co-author of standard handbooks, Dr. Cote has published more than 300 scientific papers/documents, which have received 10,000 citations.
Ram Datar, Ph. D., is Co-Director, Biomedical Nanotechnology Institute, the University of Miami, Associate Professor, Pathology, Associate Professor, Biochemistry and Molecular Biology, the University of Miami Miller School of Medicine. Dr. Datar's areas of research focus include cancer
molecular pathology and biomedical nanotechnology. Specifically, he hasbeen involved in various aspects of detection and molecular characterization of occult metastases in cancers. For many years, he has also been involved in the development and application of micro- and nanoscale devices for biomedical diagnostic applications. His goal is to employ microfabrication and develo
pment of microfluidic devices to further novel technologydevelopment, including biosensors and molecular methods to analyze expression profiles of cancers. Dr. Datar's many publications have received more than 2,200 citations.
Bibliographic Information
Book Title: Circulating Tumor Cells
Editors: Richard J. Cote, Ram H. Datar
Series Title: Current Cancer Research
DOI: https://doi.org/10.1007/978-1-4939-3363-1
Publisher: Springer New York, NY
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2016
Softcover ISBN: 978-1-4939-8031-4Published: 30 March 2018
eBook ISBN: 978-1-4939-3363-1Published: 03 February 2016
Series ISSN: 2199-2584
Series E-ISSN: 2199-2592
Edition Number: 1
Number of Pages: XXIV, 333
Number of Illustrations: 2 b/w illustrations, 29 illustrations in colour
Topics: Cancer Research