Diffusion Tensor Imaging

1. Front Matter

   Pages i-xviii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. How to Use this Book

      • Louise Emsell

      Pages 3-5

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   3. Introduction to Diffusion Tensor Imaging

      • Louise Emsell, Wim Van Hecke, Jacques-Donald Tournier

      Pages 7-19

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3. Diffusion Tensor Imaging: From Theory to Practice

   1. Front Matter

      Pages 21-21

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   2. Concepts of Diffusion in MRI

      • Matthew Rowe, Bernard Siow, Daniel C. Alexander, Uran Ferizi, Simon Richardson

      Pages 23-35

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   3. From Diffusion to the Diffusion Tensor

      • Thijs Dhollander

      Pages 37-63

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   4. Quantitative DTI Measures

      • Kathleen M. Curran, Louise Emsell, Alexander Leemans

      Pages 65-87

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   5. Survivor’s Guide to DTI Acquisition

      • Eric Peterson, Roland Bammer

      Pages 89-126

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   6. Checking and Correcting DTI Data

      • Chantal M. W. Tax, Sjoerd B. Vos, Alexander Leemans

      Pages 127-150

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4. Diffusion Tensor Imaging Analysis

   1. Front Matter

      Pages 151-151

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   2. Strategies and Challenges in DTI Analysis

      • Wim Van Hecke, Louise Emsell

      Pages 153-173

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   3. DTI Analysis Methods: Region of Interest Analysis

      • Martijn Froeling, Pim Pullens, Alexander Leemans

      Pages 175-182

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   4. DTI Analysis Methods: Voxel-Based Analysis

      • Wim Van Hecke, Alexander Leemans, Louise Emsell

      Pages 183-203

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   5. DTI Analysis Methods: Fibre Tracking and Connectivity

      • Matthan W. A. Caan

      Pages 205-228

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5. Normal Diffusion Tensor Imaging Anatomy

   1. Front Matter

      Pages 229-229

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   2. Normal Diffusion Tensor Imaging-Based White Matter Anatomy

      • Bram Stieltjes

      Pages 231-271

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6. Clinical Applications of Diffusion Tensor Imaging

   1. Front Matter

      Pages 273-273

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   2. DTI in Clinical Practice: Opportunities and Considerations

      • Louise Emsell, Stefan Sunaert

      Pages 275-290

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   3. DTI in Neurosurgical Planning

      • Ronald L. Wolf, Paolo G. Nucifora, Elias R. Melhem

      Pages 291-308

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This book provides an overview of the practical aspects of diffusion tensor imaging (DTI), from understanding the basis of the technique through selection of the right protocols, trouble-shooting data quality, and analyzing DTI data optimally. DTI is a non-invasive magnetic resonance imaging (MRI) technique for visualizing and quantifying tissue microstructure based on diffusion. The book discusses the theoretical background underlying DTI and advanced techniques based on higher-order models and multi-shell diffusion imaging. It covers the practical implementation of DTI; derivation of information from DTI data; and a range of clinical applications, including neurosurgical planning and the assessment of brain tumors. Its practical utility is enhanced by decision schemes and a fully annotated DTI brain atlas, including color fractional anisotropy maps and 3D tractography reconstructions of major white matter fiber bundles. Featuring contributions from leading specialists in the field ofDTI, Diffusion Tensor Imaging: A Practical Handbook is a valuable resource for radiologists, neuroradiologists, MRI technicians and clinicians.

• diffusion kurtosis imaging
• functional imaging
• high angular resolution diffusion imaging
• quantitative brain imaging
• tractography
• voxel-based analysis
• Diagnostic Radiology

• icometrix; Department of Radiology, Department of Radiology, Antwerp University Hospital, Leuven, Belgium

  Wim Van Hecke

• Departments of Translational MRI and Radiology, KU Leuven and University Hospitals Leuven, Leuven, Belgium

  Louise Emsell, Stefan Sunaert

Wim Van Hecke, PhD, is an international expert in MRI analysis and advanced neuroimaging techniques and applications. An academic engineer by training with two Masters degrees in applied biomedical engineering and neuroimaging, and a PhD in diffusion MRI analysis, Dr. Van Hecke presently divides his time between pursuing research in advanced DTI analysis at Antwerp University Hospital and managing the business operations of icoMetrix, a rapidly expanding medical image analysis service that he co-founded to make state-of-the-art image analysis accessible to all.

Louise Emsell, PhD, is a translational neuroimaging expert and educator. Presently based at the University Psychiatry Centre (UPC) and Translational MRI departments at the KU Leuven University Hospital in Belgium, Dr. Emsell has two Masters degrees in Science (Medical Physics/Medicinal Chemistry) and Education, and a PhD in Psychiatry. Her award-winning postdoctoral research combines many advanced neuroimaging techniques, including state-of-the-art diffusion MRI, to study the development and evolution of psychopathology.

Stefan Sunaert, MD, PhD, is a Consultant Neuroradiologist, Professor of Neuroradiology and internationally-renowned expert in all aspects of clinical and academic MR neuroimaging. Presently head of the Translational MRI Department at KU Leuven, and based in the Radiology Department of the KU Leuven University Hospital in Belgium, Professor Sunaert has published widely in the field of Neuroradiology and has received numerous awards for his academic research. Additionally, he is a highly-respected clinician and educator who has organised numerous advanced neuroimaging courses and workshops at conferences across the world.

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