Overview
- Includes cutting-edge methods and protocols for studying protein amyloid aggregation
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 1345)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (20 protocols)
-
Front Matter
-
Kinetics/Mechanism
-
Front Matter
-
-
Fibrils
-
Front Matter
-
-
Computational Approaches
-
Front Matter
-
Keywords
About this book
This detailed volume focuses on methods for the characterization of aggregation processes that lead to the formation of amyloid fibrils and amyloid oligomers which feature in the etiology of a variety of human disorders collectively known as amyloidoses. The scope of the collection includes techniques for visualizing early steps on the amyloid formation pathway, methods for capturing and characterizing oligomeric, potentially toxic, intermediates, strategies for preparing and characterizing mature amyloid fibrils and approaches for understanding templating and transmission of amyloid aggregates. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Protein Amyloid Aggregation: Methods and Protocols serves as an ideal guide for biochemists and biophysicists with an interest in elucidating the mechanisms of protein amyloid formation, as well as chemists, pharmacologists and clinicians with an interest in leveraging an understanding of such mechanisms for the purpose of therapeutic development.
Editors and Affiliations
Bibliographic Information
Book Title: Protein Amyloid Aggregation
Book Subtitle: Methods and Protocols
Editors: David Eliezer
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-2978-8
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2016
Hardcover ISBN: 978-1-4939-2977-1Published: 11 October 2015
Softcover ISBN: 978-1-4939-5005-8Published: 23 August 2016
eBook ISBN: 978-1-4939-2978-8Published: 09 October 2015
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIV, 314
Number of Illustrations: 24 b/w illustrations, 49 illustrations in colour
Topics: Protein Science