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  • © 2015

Precision Molecular Pathology of Breast Cancer

  • Provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors
  • Highlights practical issues seen in practice today
  • Written by experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Molecular Pathology Library (MPLB, volume 10)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
  2. Molecular Basis of Breast Cancer Imaging

    • Gopal R. Vijayaraghavan, Srinivasan Vedantham, Ashraf Khan, Andrew Karellas
    Pages 1-14
  3. Familial Breast Cancer and Genetic Predisposition in Breast Cancer

    • Vighnesh Walavalkar, Ashraf Khan, Dina Kandil
    Pages 15-37
  4. Modelling the Molecular Pathology of Breast Cancer Initiation

    • Claire Nash, Andrew M. Hanby, Valerie Speirs
    Pages 39-50
  5. Molecular Pathology of Precancerous Lesions of the Breast

    • Abhik Mukherjee, Ian O. Ellis, Emad A. Rakha
    Pages 51-62
  6. Breast Cancer Stem Cells: Role in Tumor Initiation, Progression, and Targeted Therapy

    • Sanjoy Samanta, Ashraf Khan, Arthur M. Mercurio
    Pages 63-77
  7. Molecular Pathology of Pre-Invasive Ductal Carcinoma

    • Yuna Gong, Dina Kandil, Ashraf Khan
    Pages 79-93
  8. Molecular Pathology of Lobular Carcinoma

    • Ali Sakhdari, Lloyd Hutchinson, Ediz F. Cosar
    Pages 95-105
  9. Molecular Classification of Breast Cancer

    • Mohammed A. Aleskandarany, Ian O. Ellis, Emad A. Rakha
    Pages 137-155
  10. Molecular-Based Diagnostic, Prognostic and Predictive Tests in Breast Cancer

    • Abir A. Muftah, Mohammed A. Aleskandarany, Ian O. Ellis, Emad A. Rakha
    Pages 177-195
  11. Role of MicroRNAs in Breast Cancer

    • Jennifer L. Clark, Dina Kandil, Ediz F. Cosar, Ashraf Khan
    Pages 197-218
  12. Molecular Pathology of Fibroepithelial Neoplasms of the Breast

    • Michelle Yang, Dina Kandil, Ashraf Khan
    Pages 219-235
  13. Molecular Features of Mesenchymal Tumors of the Breast

    • Marjan Mirzabeigi, Ashraf Khan, Dina Kandil
    Pages 237-269
  14. Molecular Pathology of Breast Cancer Metastasis

    • Mohammed A. Aleskandarany, Ian O. Ellis, Emad A. Rakha
    Pages 271-289
  15. The Molecular Pathology of Chemoresistance During the Therapeutic Response in Breast Cancer

    • James L. Thorne, Andrew M. Hanby, Thomas A. Hughes
    Pages 291-307
  16. The Molecular Pathology of Male Breast Cancer

    • Rebecca A. Millican-Slater, Valerie Speirs, Thomas A. Hughes, Andrew M. Hanby
    Pages 309-315
  17. Specimens for Molecular Testing in Breast Cancer

    • Ali Sakhdari, Lloyd Hutchinson, Ediz F. Cosar
    Pages 317-327

About this book

This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2.

Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Reviews

“For pathologists and other physicians looking for a good, comprehensive reference on the molecular pathology of breast lesions, this book offers a good summary of this complex field. Chapters are overall well written, making this a reader friendly resource for pathologists who deal with the interpretation of these molecular findings. This book would be a valuable addition to a departmental and personal library.” (Ana G. Yuil-Valdes, Doody’s Book Reviews, November, 2015)

Editors and Affiliations

  • Department of Pathology, University of Massachusetts Medical School, UMassMemorial Medical Center, Worcester, USA

    Ashraf Khan, Ediz F. Cosar, Dina Kandil

  • Department of Histopathology, University of Nottingham, Nottingham, United Kingdom

    Ian O. Ellis, Emad A. Rakha

  • Leeds Institute of Cancer and Pathology, St. James University Hospital, Leeds, United Kingdom

    Andrew M. Hanby

About the editors

Ashraf Khan, MD, FRCPath
University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Ian O. Ellis, MD, FRCPath
University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK

Andrew M. Hanby, BM, FRCPath
St. James University Hospital/University of Leeds, Leeds Institute of Cancer and Pathology, Leeds, West Yorkshire, UK

Ediz F. Cosar, MD
UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Emad Rakha, MD, PhD, FRCPath
University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK

Dina Kandil, MD
UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Bibliographic Information

  • Book Title: Precision Molecular Pathology of Breast Cancer

  • Editors: Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil

  • Series Title: Molecular Pathology Library

  • DOI: https://doi.org/10.1007/978-1-4939-2886-6

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2885-9Published: 13 August 2015

  • Softcover ISBN: 978-1-4939-4867-3Published: 22 October 2016

  • eBook ISBN: 978-1-4939-2886-6Published: 12 August 2015

  • Series ISSN: 1935-987X

  • Series E-ISSN: 1935-9888

  • Edition Number: 1

  • Number of Pages: X, 338

  • Number of Illustrations: 1 b/w illustrations, 28 illustrations in colour

  • Topics: Pathology, Oncology, Gynecology

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access