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  • © 2015

Computational Systems Toxicology

  • Features state-of-the-art computational applications that are crucial for the study of systems toxicology
  • Includes approaches ranging from data management to mathematical modelling
  • Gathers key advice and practical information to support readers in their pursuit of advancing toxicological study

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-x
  2. The Adverse Outcome Pathway: A Conceptual Framework to Support Toxicity Testing in the Twenty-First Century

    • Edward Perkins, Natàlia Garcia-Reyero, Stephen Edwards, Clemens Wittwehr, Daniel Villeneuve, David Lyons et al.
    Pages 1-26
  3. Metabolic Pathway Databases: A Word of Caution

    • Miranda D. Stobbe
    Pages 27-63
  4. Data Sources for Signature Discovery in Toxicology

    • Dragana Mitic Potkrajac, Branka Rakic, Gordana Apic, Robert B. Russell
    Pages 95-108
  5. Using a Crowdsourcing Approach for Network Verification

    • Natalia Boukharov, Jennifer S. Park
    Pages 145-160
  6. Toxicological Assessment Via Gene Network Analysis

    • Simona Iacobacci, Francesco Gregoretti, Gennaro Oliva, Roman Polishchuk, Vincenzo Belcastro
    Pages 161-180
  7. Weaving Knowledge into Biological Pathways in a Collaborative Manner

    • Yukiko Matsuoka, Kazuhiro Fujita, Samik Ghosh, Hiroaki Kitano
    Pages 181-208
  8. Quantifying the Biological Impact of Active Substances Using Causal Network Models

    • Alain Sewer, Florian Martin, Walter K. Schlage, Julia Hoeng, Manuel C. Peitsch
    Pages 223-256
  9. Analysis of Proteomic Data for Toxicological Applications

    • Bjoern Titz, Thomas Schneider, Ashraf Elamin, Florian Martin, Sophie Dijon, Nikolai V. Ivanov et al.
    Pages 257-284
  10. High-Content Screening: Understanding and Managing Mechanistic Data to Better Predict Toxicity

    • Paul Walker, Tim Smith, Kerry Frost, Sarah Kelly, Ignacio Gonzalez Suarez
    Pages 317-344
  11. Computational Data Integration in Toxicogenomics

    • Simona Constantinescu, Shana J. Sturla, Giancarlo Marra, Bernd Wollscheid, Niko Beerenwinkel
    Pages 371-392
  12. Aerosol Dosimetry Modeling Using Computational Fluid Dynamics

    • Markus Nordlund, Arkadiusz K. Kuczaj
    Pages 393-427
  13. Back Matter

    Pages 429-430

About this book

This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology. The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment.

Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.

Editors and Affiliations

  • Philip Morris International R&D, Neuchâtel, Switzerland

    Julia Hoeng, Manuel C. Peitsch

Bibliographic Information

  • Book Title: Computational Systems Toxicology

  • Editors: Julia Hoeng, Manuel C. Peitsch

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-2778-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2777-7Published: 14 September 2015

  • Softcover ISBN: 978-1-4939-5003-4Published: 29 October 2016

  • eBook ISBN: 978-1-4939-2778-4Published: 10 September 2015

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: X, 430

  • Number of Illustrations: 13 b/w illustrations, 96 illustrations in colour

  • Topics: Pharmacology/Toxicology, Systems Biology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access