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  • © 2015

Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development

  • Explores pathology in oncologic disease and beyond, into other disease areas that have not received as much attention
  • Provides practical wisdom and examples from histopathology experts to apply to drug development programs
  • Features techniques, case studies, reviews, and collections of the authors' experiences in the field

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (24 protocols)

  1. Front Matter

    Pages i-xviii
  2. Outsourcing Tissue Histopathology Investigations in Support of Clinical Trials for Novel Therapeutics: Considerations and Perspectives

    • Keith A. Wharton Jr., Benjamin H. Lee, Pierre Moulin, Dale Mongeon, Rainer Hillenbrand, Arkady Gusev et al.
    Pages 43-63
  3. Histopathology in Mouse Models of Rheumatoid Arthritis

    • Patrick Caplazi, Lauri Diehl
    Pages 65-78
  4. Markers Used for Visualization and Quantification of Blood and Lymphatic Vessels

    • Mohamed E. Salama, David A. Eberhard, Steven J. Potts
    Pages 79-85
  5. Practical Approaches to Microvessel Analysis: Hotspots, Microvessel Density, and Vessel Proximity

    • Steven J. Potts, David A. Eberhard, Mohamed E. Salama
    Pages 87-100
  6. Stereology and Computer-Based Image Analysis Quantifies Heterogeneity and Improves Reproducibility for Grading Reticulin in Myeloproliferative Neoplasms

    • Mohamed E. Salama, Erik Hagendorn, Sherrie L. Perkins, Jeff L. Kutok, A. Etman, Josef T. Prchal et al.
    Pages 117-126
  7. Development of a Tissue Image Analysis Algorithm for Celiac Drug Development

    • Erik Hagendorn, Christa Whitney-Miller, Aaron Huber, Steven J. Potts
    Pages 141-152
  8. Measuring the Messenger: RNA Histology in Formalin-Fixed Tissues

    • Steven J. Potts, Mirza Peljto, Mahipal Suraneni, Joseph S. Krueger
    Pages 175-182
  9. Algorithm-Driven Image Analysis Solutions for RNA ISH Quantification in Human Clinical Tissues

    • Mirza Peljto, Joseph S. Krueger, Nicholas D. Landis, G. David Young, Steven J. Potts, Holger Lange
    Pages 183-189
  10. Next-Generation Sequencing (NGS) in Anatomic Pathology Discovery and Practice

    • Matthew J. McGinniss, David A. Eberhard, Keith A. Wharton Jr.
    Pages 219-257
  11. Adapting HER2 Testing for a Different Organ: New Wine in Old Wineskins

    • Michael D. Lunt, Christa L. Whitney-Miller
    Pages 271-279

About this book

Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development gathers diverse experts to present state of the art guidance and application of histopathology in drug development settings ranging from discovery research to human clinical trials. While many current applications of quantitative histology and molecular pathology in the biopharmaceutical industry are focused on oncology, this volume in addition explores non-oncologic disease areas including nonalcoholic steatohepatitis, arthritis, celiac disease, myeloproliferative disorders, neurology, and wound healing. The authors write from years of experience in diagnostic practice and pharmaceutical drug development, aiming to educate pharmaceutical and academic scientists how to best use tissue to diagnose disease and improve the process of drug development.  As part of the Methods in Pharmacology and Toxicology series, this volume is designed to provide wisdom and examples that others can follow and apply as part of drug development.

Comprehensive and practical, Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development will inform and enlighten both tissue-focused and non-tissue-focused drug development professionals about better use and interpretation of the multidimensional data contained in a tissue biopsy.

Editors and Affiliations

  • Flagship Biosciences, LLC, Westminster, USA

    Steven J. Potts

  • University of North Carolina, Chapel Hill, USA

    David A. Eberhard

  • Novartis Institutes for BioMedical Research, Cambridge, USA

    Keith A. Wharton, Jr.

Bibliographic Information

  • Book Title: Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development

  • Editors: Steven J. Potts, David A. Eberhard, Keith A. Wharton, Jr.

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-2681-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2680-0Published: 15 June 2015

  • Softcover ISBN: 978-1-4939-5420-9Published: 29 October 2016

  • eBook ISBN: 978-1-4939-2681-7Published: 15 June 2015

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XVIII, 375

  • Number of Illustrations: 20 b/w illustrations, 37 illustrations in colour

  • Topics: Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access