Overview
- Editors:
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Henry J. Leese
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Hertford Building, Hull York Medical School University of Hull, Hull, United Kingdom
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Daniel R. Brison
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St. Mary's Hospital Department of Reproductive Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
- Edited by two leaders in the field of reproductive biology
- One of the first books on cell signaling in early embryo development
- Covers signaling events from the zygote embryo through to the blastocyst
- Includes supplementary material: sn.pub/extras
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Table of contents (7 chapters)
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- Judith J. Eckert, Miguel A. Velazquez, Tom P. Fleming
Pages 1-21
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- Fuller W. Bazer, Gregory A. Johnson, G. Wu
Pages 23-52
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- Elizabeth E. Puscheck, Awoniyi O. Awonuga, Yu Yang, Zhongliang Jiang, Daniel A. Rappolee
Pages 77-128
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- C. O’Neill, Y. Li, X.L. Jin
Pages 129-149
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- Sarah A. Robertson, Peck-Yin Chin, John E. Schjenken, Jeremy G. Thompson
Pages 173-213
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Back Matter
Pages 215-216
About this book
The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.
Editors and Affiliations
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Hertford Building, Hull York Medical School University of Hull, Hull, United Kingdom
Henry J. Leese
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St. Mary's Hospital Department of Reproductive Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
Daniel R. Brison
About the editors
Henry Leese, PhD, is a Professor of Biology at Hull York Medical School and the founding Editor-in-Chief of Human Fertility. Daniel Brison, PhD, is Honorary Professor of Clinical Embryology and Stem Cell Biology; Scientific Director of the Department of Reproductive Medicine; and Co-Director NW Embryonic Stem Cell Centre (NWESCC) at Central Manchester University Hospitals NHS Foundation Trust at St. Mary’s Hospital.
