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Gene Delivery and Therapy for Neurological Disorders

  • Book
  • © 2015

Overview

Editors:
  1. Xuenong Bo

    1. Queen Mary University of London, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Joost Verhaagen

    1. Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques to explore gene therapy for neurological disorders
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 98)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Adeno-Associated Vectors for Gene Delivery to the Nervous System

    • Pádraig J. Mulcahy, Christopher Binny, Bartosz Muszynski, Evangelia Karyka, Mimoun Azzouz
    Pages 1-22

  3. Lentiviral Vectors for Gene Delivery to the Nervous System

    • Ioanna Eleftheriadou, Nicholas D. Mazarakis
    Pages 23-66

  4. Gene Therapy for Parkinson’s Disease: AAV5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)

    • Bas Blits, Deniz Kirik, Harald Petry, Stephan Hermening
    Pages 67-83

  5. Gene Delivery and Gene Therapy for Alzheimer’s Disease

    • Maya Woodbury, Tomomi Kiyota, Tsuneya Ikezu
    Pages 85-120

  6. Gene Therapy for Huntington’s Disease

    • Angela Wu, Dahna M. Fong, Deborah Young
    Pages 121-151

  7. Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury

    • Xuenong Bo, Yi Zhang
    Pages 153-174

  8. Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors

    • Nitish D. Fagoe, Ruben Eggers, Joost Verhaagen, Matthew R. J. Mason
    Pages 175-189

  9. Targeted Gene Therapy for Ischemic Stroke

    • Fanxia Shen, Hua Su
    Pages 191-202

  10. Adeno-Associated Viral Gene Therapy for Retinal Disorders

    • Samantha R. de Silva, Michelle E. McClements, Mark W. Hankins, Robert E. MacLaren
    Pages 203-228

  11. Gene Therapy for Epilepsies

    • En-Ju D. Lin, Matthew J. During
    Pages 229-264

  12. AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement

    • Diane Golebiowski, Allison M. Bradbury, Churl-Su Kwon, Imramsjah M. J. van der Bom, Lorelei Stoica, Aime K. Johnson et al.
    Pages 265-295

  13. Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice

    • Monir Shababi, Erkan Y. Osman, Christian L. Lorson
    Pages 297-320

  14. Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?

    • Isabel Martins, Isaura Tavares
    Pages 321-339

  15. Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models

    • John Lynes, Carl Koschmann, Mia Wibowo, Vandana Saxena, Marianela Candolfi, Mariela A. Moreno Ayala et al.
    Pages 341-354

  16. Back Matter

    Pages 355-359
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Keywords

About this book

This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors’ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer’s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work.  Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab.

Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

Editors and Affiliations

  • Queen Mary University of London, London, United Kingdom

    Xuenong Bo

  • Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

    Joost Verhaagen

Bibliographic Information

  • Book Title: Gene Delivery and Therapy for Neurological Disorders

  • Editors: Xuenong Bo, Joost Verhaagen

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-4939-2306-9

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2305-2Published: 04 February 2015

  • Softcover ISBN: 978-1-4939-5316-5Published: 05 October 2016

  • eBook ISBN: 978-1-4939-2306-9Published: 03 February 2015

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XIV, 359

  • Number of Illustrations: 14 b/w illustrations, 51 illustrations in colour

  • Topics: Neurosciences, Human Genetics, Neurology

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