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  • © 2015

Mitochondrial Medicine

Volume II, Manipulating Mitochondrial Function

  • Includes cutting-edge methods and protocols for the manipulation of mitochondrial function
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1265)

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Table of contents (33 protocols)

  1. Front Matter

    Pages i-xxiii
  2. Targeting Mitochondria with Small Molecules: The Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide

    • Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, Richard C. Hartley
    Pages 25-50
  3. Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes

    • Parul Benein, Mohammed A. Almuteri, Ahmed S. Mehanna, Gerard G. M. D’Souza
    Pages 51-57
  4. Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria

    • José Teixeira, Pedro Soares, Sofia Benfeito, Michael P. Murphy, Paulo J. Oliveira, Fernanda Borges
    Pages 73-83
  5. Mitochondriotropic Nanoemulsified Genistein-Loaded Vehicles for Cancer Therapy

    • Jimmy Pham, Oliver Grundmann, Tamer Elbayoumi
    Pages 85-101
  6. Formulation and Optimization of Mitochondria-Targeted Polymeric Nanoparticles

    • Sean Marrache, Rakesh K. Pathak, Shanta Dhar
    Pages 103-112
  7. Ex Vivo Generation of Functional Immune Cells by Mitochondria-Targeted Photosensitization of Cancer Cells

    • Sean Marrache, Smanla Tundup, Donald A. Harn, Shanta Dhar
    Pages 113-122
  8. Mitochondrial, Acidic, and Cytosolic pHs Determination by 31P NMR Spectroscopy: Design of New Sensitive Targeted pH Probes

    • Marcel Culcasi, Sophie Thétiot-Laurent, Ariane Atteia, Sylvia Pietri
    Pages 135-147
  9. Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research

    • Mikhail Y. Vyssokikh, Yury N. Antonenko, Konstantin G. Lyamzaev, Tatyana I. Rokitskaya, Vladimir P. Skulachev
    Pages 149-159
  10. Synthesis and Testing of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin

    • Lucia Biasutto, Andrea Mattarei, Cristina Paradisi
    Pages 161-179
  11. Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents

    • Katarina Kluckova, Lan-Feng Dong, Martina Bajzikova, Jakub Rohlena, Jiri Neuzil
    Pages 181-194
  12. The Effect of Mitochondrially Targeted Anticancer Agents on Mitochondrial (Super)Complexes

    • Magdalena Vondrusova, Ayanachew Bezawork-Geleta, Karishma Sachaphibulkij, Jaroslav Truksa, Jiri Neuzil
    Pages 195-208
  13. Mitochondrial Targeting of Recombinant RNA

    • Ilya Dovydenko, Anne-Marie Heckel, Yann Tonin, Ali Gowher, Alya Venyaminova, Ivan Tarassov et al.
    Pages 209-225
  14. Mitochondrial Targeting of Catalytic RNAs

    • Daria Mileshina, Adnan Khan Niazi, Eliza Wyszko, Maciej Szymanski, Romain Val, Clarisse Valentin et al.
    Pages 227-254
  15. Analysis of Pollutant-Induced Changes in Mitochondrial DNA Methylation

    • Hyang-Min Byun, Timothy M. Barrow
    Pages 271-283

About this book

This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

Editors and Affiliations

  • Midwestern University, Glendale, USA

    Volkmar Weissig

  • ISANH, Paris, France

    Marvin Edeas

Bibliographic Information

  • Book Title: Mitochondrial Medicine

  • Book Subtitle: Volume II, Manipulating Mitochondrial Function

  • Editors: Volkmar Weissig, Marvin Edeas

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-2288-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2287-1Published: 30 January 2015

  • Softcover ISBN: 978-1-4939-5605-0Published: 05 October 2016

  • eBook ISBN: 978-1-4939-2288-8Published: 29 January 2015

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XXIII, 447

  • Number of Illustrations: 59 b/w illustrations, 65 illustrations in colour

  • Topics: Pharmacology/Toxicology, Laboratory Medicine

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access