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  • © 2015

Unexplained Infertility

Pathophysiology, Evaluation and Treatment

  • A unique compilation of the experience and insights of leading specialists, clinicians and scientists with expertise in male and female infertility

  • An invaluable tool for basic scientists with an interest in reproductive medicine and for clinicians working in the field of infertility - urologists, gynecologists, reproductive endocrinologists and embryologists

  • Practically organized into sections on epidemiology, male and female pathophysiology, evaluation, medical and surgical management strategies and ART

  • Includes supplementary material: sn.pub/extras

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Table of contents (33 chapters)

  1. Front Matter

    Pages i-xvi
  2. Definitions and Epidemiology

    1. Front Matter

      Pages 1-1
    2. Definitions and Relevance of Unexplained Infertility in Reproductive Medicine

      • Sandro C. Esteves, Glenn L. Schattman, Ashok Agarwal
      Pages 3-5
    3. Definitions and Epidemiology of Unexplained Male Infertility

      • Ahmet Gudeloglu, Jamin Brahmbhatt, Sijo Parekattil
      Pages 7-12
    4. Definitions and Epidemiology of Unexplained Female Infertility

      • Luciano G. Nardo, Spyridon Chouliaras
      Pages 21-25
  3. Pathophysiology: Male

    1. Front Matter

      Pages 27-27
    2. Sperm Biology from Production to Ejaculation

      • Damayanthi Durairajanayagam, Anil K. Rengan, Rakesh K. Sharma, Ashok Agarwal
      Pages 29-42
    3. Idiopathic Infertility: Survival and Function of Sperm in the Female Reproductive Tract

      • Michelle van der Linde, Stefan S. du Plessis
      Pages 43-51
    4. Potential Male Etiologies of Unexplained Infertility

      • Brent M. Hardin, Edward D. Kim
      Pages 53-56
    5. Genetic Basis of Unexplained Male Infertility

      • Ricardo Miyaoka, Sandro C. Esteves
      Pages 57-70
    6. Role of the Immune System in Unexplained Male Infertility

      • Rajesh K. Naz, Walter K. H. Krause
      Pages 71-80
    7. Oxidative Stress in Unexplained Male Infertility

      • Sejal B. Doshi, Rakesh K. Sharma, Ashok Agarwal
      Pages 81-89
    8. Role and Significance of Sperm Function in Men with Unexplained Infertility

      • Sandro C. Esteves, Sidney Verza, Rakesh K. Sharma, Jaime Gosálvez, Ashok Agarwal
      Pages 91-119
    9. Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Male Infertility

      • Pieter Johann Maartens, Yapo Guillaume Aboua, Stefan S. Plessis
      Pages 121-138
  4. Pathophysiology: Female

    1. Front Matter

      Pages 139-139
    2. Potential Etiologies of Unexplained Infertility in Females

      • Daniela Galliano, Antonio Pellicer
      Pages 141-147
    3. Oxidative Stress in Unexplained Female Infertility

      • Fatma Ferda Verit
      Pages 149-159
    4. Cervical Hostility and Vaginal pH in Females with Unexplained Infertility

      • Fabiana Y. Nakano, Rogério de Barros Ferreira Leão, Sandro C. Esteves
      Pages 175-183

About this book

Written and edited by leading, internationally recognized clinicians and scientists in reproductive medicine and related fields, this unique text is a practical and comprehensive review of the clinical and scientific significance of unexplained male and female infertility and its management. The book is divided into thematic sections to ensure the most useful presentation of topics, opening with definitions and epidemiology of unexplained infertility, including discussion of the WHO’s cutoff values for human semen characteristics and its ramifications. Sections covering male and female reproductive pathophysiology follow respectively, covering biological, genetic and environmental causative factors, with a subsequent section on evaluative techniques for male and female patients. Expectant, medical and surgical treatment strategies comprise the fifth section of the book, where active interventions and outcomes of each treatment modality are carefully considered. The final section discusses assisted reproductive techniques to manage unexplained infertility, such as intrauterine insemination and in vitro fertilization, as well as future perspectives. Thoughtful and enlightening, Unexplained Infertility: Pathophysiology, Evaluation and Treatment will be an invaluable resource for all clinicians and scientists working in the fields of reproductive medicine and infertility.

Editors and Affiliations

  • Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, USA

    Glenn L. Schattman

  • Andrology and Human Reproduction Clinic Referral Center for Male Reproduction, ANDROFERT, Campinas, Brazil

    Sandro C. Esteves

  • Andrology Center & Center for Reproductive Medicine, Lerner College of Medicine Case Western Reserve University, Cleveland, USA

    Ashok Agarwal

About the editors

Glenn L. Schattman, MD, Center for Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA

Sandro C. Esteves, MD, PhD, ANDROFERT, Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, Campinas, São Paulo, Brazil

Ashok Agarwal, PhD, HCLD (ABB), ELD (ACE), Lerner College of Medicine, Case Western Reserve University, Andrology Center and Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA

Bibliographic Information

  • Book Title: Unexplained Infertility

  • Book Subtitle: Pathophysiology, Evaluation and Treatment

  • Editors: Glenn L. Schattman, Sandro C. Esteves, Ashok Agarwal

  • DOI: https://doi.org/10.1007/978-1-4939-2140-9

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2015

  • Hardcover ISBN: 978-1-4939-2139-3Published: 13 May 2015

  • Softcover ISBN: 978-1-4939-4432-3Published: 12 October 2016

  • eBook ISBN: 978-1-4939-2140-9Published: 12 May 2015

  • Edition Number: 1

  • Number of Pages: XVI, 358

  • Number of Illustrations: 11 b/w illustrations, 45 illustrations in colour

  • Topics: Reproductive Medicine, Gynecology, Urology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access