Editors:
- Informs readers how systems medicine may lead to new advances in blood pathophysiology and treatment
- Overview of how blood and its diseases have provided an ideal model to study topics of stem cell biology
- Topics include intracellular signaling, cellular interactions and diseases of the blood system
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 844)
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Table of contents (19 chapters)
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Front Matter
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Basic Components
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Front Matter
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Physiological Processes
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Front Matter
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About this book
The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels.
A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
Editors and Affiliations
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Departments of Pediatrics and Cell & Molecular Biology, Northwestern University Feinberg School of Medicine and Lurie Children’s Hospital of Chicago, Chicago, USA
Seth Joel Corey
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Department of Statistics, Rice University, Houston, USA
Marek Kimmel
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Northwestern University Comprehensive Cancer Center, Evanston, USA
Joshua N. Leonard
Bibliographic Information
Book Title: A Systems Biology Approach to Blood
Editors: Seth Joel Corey, Marek Kimmel, Joshua N. Leonard
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4939-2095-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2014
Hardcover ISBN: 978-1-4939-2094-5Published: 06 December 2014
Softcover ISBN: 978-1-4939-4284-8Published: 10 September 2016
eBook ISBN: 978-1-4939-2095-2Published: 06 December 2014
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: IX, 403
Number of Illustrations: 21 b/w illustrations, 52 illustrations in colour
Topics: Biomedicine general, Systems Biology, Hematology