Humanized Mice for HIV Research

Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria.

Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

• HIV
• Immune system function
• Mouse-to-human xenotransplantation
• humanized mice

“Humanized Mice for HIV Research is a comprehensive overview of human immune engrafted mouse models as they apply to HIV, but also with relevance to other fields of study. … Although the work is titled, this book also includes a section on modeling other human specific/selection pathogens in human immune system mice. … Humanized Mice for HIV Research is an excellent reference, not just for HIV researchers, but also for anyone interested in working with immune engrafted models.” (Megan M. MacBride, Taconic Biosciences, taconic.com, January, 2016)

• Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, USA

  Larisa Y. Poluektova

• Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, USA

  J. Victor Garcia

• Research Center for AIDS Laboratory of Viral Pathogenesis, Kyoto University Institute for Virus Research, Sakyo-ku, Japan

  Yoshio Koyanagi

• Division of Hematology, University Hospital Zürich, Zürich, Switzerland

  Markus G. Manz

• Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA

  Andrew M. Tager

Larisa Y. Poluektova, University of Nebraska Medical Center, Omaha, USA

J. Victor Garcia, University of North Carolina at Chapel Hill, USA

Yoshio Koyanagi, Kyoto University, Japan

Markus G. Manz, University Hospital Zürich, Switzerland

Andrew M. Tager, Massachusetts General Hospital and Ragon Institute of MGH, MIT and Harvard, USA). 

Policies and ethics