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Technical Aspects of Toxicological Immunohistochemistry

System Specific Biomarkers

  • Book
  • © 2016

Overview

Editors:
  1. Syed A. Aziz

    1. Health Products and Food Branch Health Canada, Regulatory Toxicology Research Division Food Directorate, Ottawa, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Rekha Mehta

    1. Health Products and Food Branch Health Canada, Regulatory Toxicology Research Division Food Directorate, Ottawa, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues
  • Explores the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification
  • Important reference for immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Immunohistochemistry: Overview, Its Potential, and Challenges

    • Syed A. Aziz, Rekha Mehta
    Pages 1-4

  3. Tissue Microarray Technology and Its Potential Applications in Toxicology and Toxicological Immunohistochemistry

    • Ali Mobasheri
    Pages 5-20

  4. Importance of Fluorescent In Situ Hybridization in Rodent Tumors

    • Ana Mendes-da-Silva, Filomena Adega, Raquel Chaves
    Pages 21-49

  5. Quantitation of Immunohistochemistry by Image Analysis Technique

    • Klaus Kayser, Gian Kayser
    Pages 51-71

  6. Immunohistochemistry in the Study of Cancer Biomarkers for Oncology Drug Development

    • Fang Jiang, Evelyn M. McKeegan
    Pages 73-94

  7. Male Reproductive Toxicology and the Role of Immunohistochemistry

    • Daniel G. Cyr
    Pages 95-111

  8. Immunohistochemistry and Female Reproductive Toxicology: The Ovary and Mammary Glands

    • Daniel G. Cyr, Patrick J. Devine, Isabelle Plante
    Pages 113-145

  9. Immunohistochemistry on Rodent Circulatory System: Its Possible Use in Investigating Hypertension

    • Chun-Yi Ng, Yusof Kamisah, Kamsiah Jaarin
    Pages 147-177

  10. Role of Lymphoid/Mucosa-Associated Lymphoid Tissue Markers in Toxicological Immunohistochemistry

    • Kuldeep Singh, E. Driskell, A. Stern
    Pages 179-192

  11. Bone Marker and Immunohistochemistry Changes in Toxic Environments

    • Ahmad Nazrun Shuid, Isa Naina Mohamed, Norliza Muhammad, Elvy Suhana Mohd Ramli, Norazlina Mohamed
    Pages 193-213

  12. Biomarkers of Skeletal Muscle Injury in the Rat

    • Nivaldo A. Parizotto, Natalia C. Rodrigues, Paulo Sergio Bossini, Michael R. Hamblin
    Pages 215-226

  13. Back Matter

    Pages 227-231
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Keywords

About this book

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

Editors and Affiliations

  • Health Products and Food Branch Health Canada, Regulatory Toxicology Research Division Food Directorate, Ottawa, Canada

    Syed A. Aziz, Rekha Mehta

About the editors

Syed A Aziz, Ph.D.

Regulatory Toxicology Research Division, Bureau of Chemical Safety

Food Directorate, Health Products and Food Branch

Health Canada

Adjunct professor, Faculty of Medicine Dept. of Pathology

University of Ottawa

Rekha Mehta, Ph.D.

Regulatory Toxicology Research Division, Bureau of Chemical Safety

Food Directorate, Health Products and Food Branch

Health Canada.

Bibliographic Information

  • Book Title: Technical Aspects of Toxicological Immunohistochemistry

  • Book Subtitle: System Specific Biomarkers

  • Editors: Syed A. Aziz, Rekha Mehta

  • DOI: https://doi.org/10.1007/978-1-4939-1516-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-1515-6Published: 24 December 2015

  • Softcover ISBN: 978-1-4939-7965-3Published: 27 March 2019

  • eBook ISBN: 978-1-4939-1516-3Published: 23 December 2015

  • Edition Number: 1

  • Number of Pages: XI, 231

  • Number of Illustrations: 50 b/w illustrations, 3 illustrations in colour

  • Topics: Cell Biology, Pharmacology/Toxicology, Biological Microscopy, Pathology

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