Overview
- Provides case studies of RNA binding proteins that regulate aspects of RNA processing
- Focuses on global protein-RNA interactions to understand disease and development
- First book on systems biology of RNA Binding Proteins
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 825)
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Table of contents (13 chapters)
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Front Matter
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Back Matter
Keywords
About this book
After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative “mRNP code”. These cis-regulatory RNA elements can be found in the 5’ and 3’ untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5’ and 3’ UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3’ end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA.
This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases.
Editors and Affiliations
Bibliographic Information
Book Title: Systems Biology of RNA Binding Proteins
Editors: Gene W. Yeo
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4939-1221-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2014
Hardcover ISBN: 978-1-4939-1220-9Published: 09 September 2014
Softcover ISBN: 978-1-4939-5434-6Published: 10 September 2016
eBook ISBN: 978-1-4939-1221-6Published: 08 September 2014
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: X, 468
Number of Illustrations: 2 b/w illustrations, 52 illustrations in colour
Topics: Systems Biology, Protein Science, Gene Expression