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Neuroinflammation and Neurodegeneration

  • Book
  • © 2014

Overview

Editors:
  1. Phillip K. Peterson

    1. Department of Medicine, University of Minnesota Medical School, Minneapolis, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Michal Toborek

    1. Department of Biochemistry Department of Molecular Biology, University of Miami School of Medicine, Miami, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology
  • Looks at the convergence of the immune system and the loss of neurons in diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis and Huntington’s
  • Contains a section on novel approaches to therapy
  • Includes supplementary material: sn.pub/extras

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Mechanisms of Brain Defense and Neuropathogenesis

    1. Front Matter

      Pages 1-1
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    2. The Blood-Brain Barrier

      • Victor Castro, Michal Toborek
      Pages 3-28

    3. Immune Cell Trafficking in the Central Nervous System

      • Beena John, Christopher A. Hunter, Tajie H. Harris
      Pages 29-45

    4. General Physiology and Pathophysiology of Microglia

      • Alexei Verkhratsky, Mami Noda
      Pages 47-60

    5. Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases

      • Gordon P. Meares, Etty N. Benveniste
      Pages 61-80

    6. Oxidative Stress, Neuroinflammation, and Neurodegeneration

      • Hui-Ming Gao, Hui Zhou, Jau-Shyong Hong
      Pages 81-104

    7. Peripheral Neuroimmune Interactions and Neuropathic Pain

      • Halina Machelska
      Pages 105-116

  3. Neurological Diseases and Inflammation

    1. Front Matter

      Pages 117-117
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    2. Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson’s Disease

      • Rebecca A. Wilshusen, R. Lee Mosley
      Pages 119-142

    3. Multiple Sclerosis: Impact on Functioning of the Blood–Brain Barrier

      • Mark R. Mizee, Gijs Kooij, Helga E. de Vries
      Pages 143-160

    4. Neuroinflammation in Alzheimer’s Disease

      • Veronika M. Reinisch, Daniela L. Krause, Norbert Müller
      Pages 161-177

    5. Neuroinflammation in Huntington’s Disease

      • Roland G. W. Staal, Thomas Möller
      Pages 179-197

    6. Neuroinflammation and Immune Regulation in Ischemic Stroke: Identification of New Pharmacological Targets

      • Mario Di Napoli, Craig J. Smith, Stephen J. Hopkins, Aurel Popa-Wagner, Ana Maria Buga, Mark Slevin
      Pages 199-244

  4. Infectious Diseases

    1. Front Matter

      Pages 245-245
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    2. HIV/NeuroAIDS

      • Kelly L. Stauch, Howard S. Fox
      Pages 247-262

    3. Herpes Simplex Virus Infections of the Central Nervous System

      • Richard J. Whitley
      Pages 263-290

    4. Congenital Cytomegalovirus Disease

      • Mark R. Schleiss
      Pages 291-308

    5. Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous System

      • Kallol Dutta, Anirban Basu
      Pages 309-335

    6. The Biology and Clinical Consequence of Infection with the Human Polyomavirus JCV

      • G. von Geldern, M. J. Barhams, E. O. Major
      Pages 337-354
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Keywords

About this book

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Reviews

“This is an outstanding text and atlas of neurodegenerative & neuroinflammatory diseases. … This book is for cell biologists.” (Joseph J. Grenier, Amazon.com, November, 2015)

Editors and Affiliations

  • Department of Medicine, University of Minnesota Medical School, Minneapolis, USA

    Phillip K. Peterson

  • Department of Biochemistry Department of Molecular Biology, University of Miami School of Medicine, Miami, USA

    Michal Toborek

Bibliographic Information

  • Book Title: Neuroinflammation and Neurodegeneration

  • Editors: Phillip K. Peterson, Michal Toborek

  • DOI: https://doi.org/10.1007/978-1-4939-1071-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4939-1070-0

  • Softcover ISBN: 978-1-4939-4698-3

  • eBook ISBN: 978-1-4939-1071-7

  • Edition Number: 1

  • Number of Pages: XVII, 600

  • Number of Illustrations: 13 b/w illustrations, 35 illustrations in colour

  • Topics: Neurosciences, Neurochemistry, Neurobiology

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