Oxygen Transport to Tissue XXXVI

1. Front Matter

   Pages i-xxx

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2. Mitochondrial Genetic Abnormalities After Radiation Exposure

   • David Maguire, Steven B. Zhang, Paul Okunieff

   Pages 1-7

3. Crediting Six Discoverers of Oxygen

   • John W. Severinghaus

   Pages 9-17

4. Hypoxia in Tumors: Pathogenesis-Related Classification, Characterization of Hypoxia Subtypes, and Associated Biological and Clinical Implications

   • Peter Vaupel, Arnulf Mayer

   Pages 19-24

5. Heterogeneity in Tissue Oxygenation: From Physiological Variability in Normal Tissues to Pathophysiological Chaos in Malignant Tumours

   • David K. Harrison, Peter Vaupel

   Pages 25-31

6. Oxygen Diffusion: An Enzyme-Controlled Variable Parameter

   • Wilhelm Erdmann, Stefan Kunke

   Pages 33-41

7. Role of Microvascular Shunts in the Loss of Cerebral Blood Flow Autoregulation

   • Edwin M. Nemoto, Denis E. Bragin, Gloria Statom, Mark Krasberg, Suguna Pappu, Bobby Sena et al.

   Pages 43-49

8. Impact of Hypoxia-Related Tumor Acidosis on Cytotoxicity of Different Chemotherapeutic Drugs In Vitro and In Vivo

   • Oliver Thews, Anne Riemann, Martin Nowak, Michael Gekle

   Pages 51-58

9. The Founding of ISOTT: The Shamattawa of Engineering Science and Medical Science

   • Duane F. Bruley

   Pages 59-63

10. A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism

    • Jeff F. Dunn, Nabeela Nathoo, Runze Yang

    Pages 65-71

11. Advances in Probes and Methods for Clinical EPR Oximetry

    • Harold M. Swartz, Huagang Hou, Nadeem Khan, Lesley A. Jarvis, Eunice Y. Chen, Benjamin B. Williams et al.

    Pages 73-79

12. Real-Time, In Vivo Determination of Dynamic Changes in Lung and Heart Tissue Oxygenation Using EPR Oximetry

    • Brian K. Rivera, Shan K. Naidu, Kamal Subramanian, Matthew Joseph, Huagang Hou, Nadeem Khan et al.

    Pages 81-86

13. Modulation of Hypoxia by Magnetic Nanoparticle Hyperthermia to Augment Therapeutic Index

    • Eunice Y. Chen, Kimberley S. Samkoe, Sassan Hodge, Katherine Tai, Huagang Hou, Alicia A. Petryk et al.

    Pages 87-95

14. Skeletal Muscle and Glioma Oxygenation by Carbogen Inhalation in Rats: A Longitudinal Study by EPR Oximetry Using Single-Probe Implantable Oxygen Sensors

    • Huagang Hou, Nadeem Khan, Jean Lariviere, Sassan Hodge, Eunice Y. Chen, Lesley A. Jarvis et al.

    Pages 97-103

15. Recurrent Low-Dose Chemotherapy to Inhibit and Oxygenate Head and Neck Tumors

    • Nadeem Khan, Huagang Hou, Sassan Hodge, Muthulakshmi Kuppusamy, Eunice Y. Chen, Alan Eastman et al.

    Pages 105-111

16. How In Vivo EPR Measures and Images Oxygen

    • Boris Epel, Gage Redler, Howard J. Halpern

    Pages 113-119

17. What We Learn from In Vivo EPR Oxygen Images

    • Gage Redler, Boris Epel, Howard J. Halpern

    Pages 121-126

18. EPR Image Based Oxygen Movies for Transient Hypoxia

    • Gage Redler, Boris Epel, Howard J. Halpern

    Pages 127-133

19. Repetitive Measurements of Intrarenal Oxygenation In Vivo Using L Band Electron Paramagnetic Resonance

    • Stephanie Franzén, Liselotte Pihl, Nadeem Khan, Fredrik Palm, Håkan Gustafsson

    Pages 135-141

20. Quantitative Hypoxia Imaging for Treatment Planning of Radiotherapy

    • Iuliana Toma-Dasu, Alexandru Dasu

    Pages 143-148

This book contains the refereed contributions from the 41st annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. Traditionally, ISOTT conferences are a place, where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 41st annual meeting. Special features in this volume include invited presentations from senior members of ISOTT for the theme “the wisdom of ISOTT” in which founders, past presidents and prize winners from previous meetings provided both cutting edge new knowledge and integratedoverviews of critical aspects of the field. The presentations and manuscripts also include those provided by the special opportunity provided by having part of the ISOTT meeting overlap with the EPR-2013 meeting where both focused on preclinical and clinical measurements of oxygen, with a particular emphasis on cancer.

Chapters 22, 24, 25 and 26 are open access under a CC BY 4.0 license via link.springer.com.

• EPR Center for the Study of Viable Systems, The Geisel School of Medicine at Dartmouth, Lebanon, USA

  Harold M. Swartz

• Microvascular Measurements, St. Lorenzen, Italy

  David K. Harrison

• Synthesizer Inc., Ellicott City, USA

  Duane F. Bruley

Policies and ethics