The Multiple Therapeutic Targets of A20

1. Front Matter

   Pages i-xxi

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2. A20—A Bipartite Ubiquitin Editing Enzyme with Immunoregulatory Potential

   • Ingrid Wertz, Vishva Dixit

   Pages 1-12

3. The Biology of A20-Binding Inhibitors of NF-κB Activation (ABINS)

   • Lynn Verstrepen, Isabelle Carpentier, Rudi Beyaert

   Pages 13-31

4. The Biology of A20-Like Molecules

   • Karine Enesa, Paul Evans

   Pages 33-48

5. Anti-Viral Tetris: Modulation of the Innate Anti-Viral Immune Response by A20

   • Meztli Arguello, Suzanne Paz, Christiane Ferran, Herwig P. Moll, John Hiscott

   Pages 49-64

6. A20 Expressing Tumors and Anticancer Drug Resistance

   • Cleide Gonçalves da Silva, Darlan Conterno Minussi, Christiane Ferran, Markus Bredel

   Pages 65-81

7. Translational Studies of A20 in Atherosclerosis and Cardiovascular Disease

   • Fiona C. McGillicuddy, Herwig P. Moll, Samira Farouk, Scott M. Damrauer, Christiane Ferran, Muredach P. Reilly

   Pages 83-101

8. A20—A Biomarker of Allograft Outcome: A Showcase in Kidney Transplantation

   • Gabor Bodonyi-Kovacs, Terry B. Strom, Prabhakar Putheti

   Pages 103-116

9. A20-An Omnipotent Protein in the Liver: Prometheus Myth Resolved?

   • Cleide Gonçalves da Silva, Jesus Revuelta Cervantes, Peter Studer, Christiane Ferran

   Pages 117-139

10. Emerging Roles for A20 in Islet Biology and Pathology

    • Nathan W. Zammit, Shane T. Grey

    Pages 141-162

11. Single Nucleotide Polymorphisms at the TNFAIP3/A20 Locus and Susceptibility/Resistance to Inflammatory and Autoimmune Diseases

    • Alessandra Mele, Jesus Revuelta Cervantes, Victor Chien, David Friedman, Christiane Ferran

    Pages 163-183

12. Back Matter

    Pages 185-188

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This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target.

• NF-KB inhibitory function
• apoptosis
• diagnostic biomarker
• endothelial cells
• inflammation

• Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, Boston, USA

  Christiane Ferran

• The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

  Christiane Ferran

Christiane Ferran, born in Beirut Lebanon, is Professor of Surgery at Harvard Medical School, Boston, Massachusetts, United States of America. She also holds an appointment as Staff Physician in the Division of Nephrology, Department of Medicine and as a Principal Research Investigator in the Division of Vascular Surgery at the Beth Israel Deaconess Medical Center (BIDMC). At BIDMC, Dr. Ferran is an active senior member of the Center for Vascular Biology Research, where she served as the chair of the Junior Faculty Mentoring Committee and of the Transplant Institute. She also chairs the Affinity Research Collaborative, an initiative aimed at fostering collaborative, interdisciplinary research program in the Department of Surgery. Main research interests include deciphering the physiologic molecular response to inflammation and how this response impacts disease pathophysiology, namely vascular diseases, allograft rejection, liver and islet regenerative processes and cellular metabolism. For the past two decades, this endeavor has mainly focused on the potent NF‑kB inhibitory protein, A20, for which she has continuously received external funding, starting in 1996 with a National Institutes of Health (NIH) funded RO1 aimed at studying the role of A20 in endothelial cell biology. Dr. Ferran is a member of numerous National and International Scientific Societies, including the American Society of Transplantation, the International Society of Transplantation, the American Society of Nephrology, the French Society of Nephrology and the American Society of Vascular Surgery. She has served as scientific reviewer on many National Institutes of Health (NIH), juvenile diabetes Research Foundation (JDRF) and Roche Organ Transplant Research Foundation (ROTRF) study sections.

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