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Cholinergic Basis for Alzheimer Therapy

  • Book
  • © 1991

Overview

Editors:
  1. Robert Becker

    1. Department of Psychiatry School of Medicine, Southern Illinois University, Springfield, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ezio Giacobini

    1. Department of Pharmacology School of Medicine, Southern Illinois University, Springfield, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Alzheimer Disease Therapy (AADT)

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Table of contents (52 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction: Cognitive Deficit in AD

    1. Therapy of the Cognitive Deficit in Alzheimer’s Disease: The Cholinergic System

      • Robert E. Becker
      Pages 1-22

  3. Cholinesterases: Anatomy, Pathology and Human Genetics

    1. Front Matter

      Pages 23-23
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    2. Cortical Cholinesterases in Alzheimer’s Disease: Anatomical and Enzymatic Shifts from the Normal Pattern

      • M.-Marsel Mesulam, Changiz Geula
      Pages 25-30

    3. Cholinesterases in Human Degenerative Diseases

      • John R. Atack
      Pages 31-37

    4. The Pathology of the Human Nucleus Basalis of Meynert and its Implications for a Specific Therapy

      • Thomas Arendt, Volker Bigl
      Pages 38-45

    5. Structure-Function Relationship Studies in Human Cholinesterases as an Approach for Evaluating Potential Pharmacotherapeutic and/Or Toxicity Effects of Cholinergic Drugs

      • Hermona Soreq, Yael Loewenstein, Lewis F. Neville, Shlomo Seidman, Revital Ben-Aziz, Gal Ehrlich et al.
      Pages 46-52

    6. Structure of the Acetylcholinesterase Gene: Regulation of Its Expression

      • Palmer Taylor, Ying Li, Shelley Camp, Tara L. Rachinsky, Damon Getman
      Pages 53-60

  4. Pharmacokinetics and Neurophysiology of Cholinesterase Inhibitors

    1. Front Matter

      Pages 61-61
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    2. Kinetics and Mechanisms of Reversible and Progressive Inhibition of Acetylcholinesterase

      • Elsa Reiner, Vera Simeon, Mira Skrinjaric-Spoljar
      Pages 63-67

    3. Clinical Pharmacokinetics of Centrally Acting Cholinesterase Inhibitors

      • Per Hartvig, Lars Wiklund, Sten Magnus Aquilonius, Björn Lindström
      Pages 68-73

    4. Pre- and Postsynaptic Effects of Cholinesterase Inhibitors

      • Lev G. Magazanik, Vadim Y. Bolshakov, Nera Y. Lukomskaya, Natalja N. Potapjeva, Marina V. Samojlova, Vladimir A. Snetkov et al.
      Pages 74-81

  5. Cholinergic Receptors, Immunocytochemistry and PET Scanning

    1. Front Matter

      Pages 83-83
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    2. Immunocytochemistry of Muscarinic and Nicotinic Receptors in Human Brain

      • Hannsjörg Schröder
      Pages 85-91

    3. Presynaptic Cholinergic Mechanisms in Human Cerebral Cortex of Adult and Aged Patients

      • Mario Marchi, Elisabetta Besana, Agnese Codignola, Paola Sanguineti, Maurizio Raiteri, Gian Carlo Andrioli et al.
      Pages 92-97

    4. Nicotinic Acetylcholine Receptors in the Human Nervous System

      • Bice Chini, Paola Tarroni, Francesca Rubboli, Elena Raimondi, Francesco Clementi
      Pages 98-106

    5. Nicotinic Receptors in the CNS as Visualized by Positron Emission Tomography

      • Agneta Nordberg, Per Hartvig, Anders Lilja, Hans Lundqvist, Ulrika Warpman, Johan Ulin et al.
      Pages 107-115

  6. Cholinergic System: Models of Alzheimer Disease, Effects of Lesions and Aging

    1. Front Matter

      Pages 117-117
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    2. Nucleus Basalis Lesions and Recovery

      • Vahram Haroutunian, William Wallace, Kenneth L. Davis
      Pages 119-125

    3. Experimental Automimmune Dementia (EAD): An Immunological Model of Memory Dysfunction and Alzheimer’s Disease

      • Daniel M. Michaelson, Gil Alroy, Lior Soussan, Joab Chapman, Joram Feldon
      Pages 126-133
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Keywords

Editors and Affiliations

  • Department of Psychiatry School of Medicine, Southern Illinois University, Springfield, USA

    Robert Becker

  • Department of Pharmacology School of Medicine, Southern Illinois University, Springfield, USA

    Ezio Giacobini

Bibliographic Information

  • Book Title: Cholinergic Basis for Alzheimer Therapy

  • Editors: Robert Becker, Ezio Giacobini

  • Series Title: Advances in Alzheimer Disease Therapy

  • DOI: https://doi.org/10.1007/978-1-4899-6738-1

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1991

  • Softcover ISBN: 978-1-4899-6740-4Published: 10 October 2013

  • eBook ISBN: 978-1-4899-6738-1Published: 21 November 2013

  • Edition Number: 1

  • Number of Pages: X, 494

  • Number of Illustrations: 23 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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