Biopsy Pathology of Muscle

1. Front Matter

   Pages i-ix

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2. Introduction

   • Michael Swash, Martin S. Schwartz

   Pages 1-14

3. The muscle biopsy: techniques and laboratory methods

   • Michael Swash, Martin S. Schwartz

   Pages 15-37

4. Histological and morphometric characteristics of normal muscle

   • Michael Swash, Martin S. Schwartz

   Pages 38-52

5. Histological features of myopathic and neurogenic disorders

   • Michael Swash, Martin S. Schwartz

   Pages 53-82

6. Inflammatory myopathies

   • Michael Swash, Martin S. Schwartz

   Pages 83-105

7. Muscular dystrophies

   • Michael Swash, Martin S. Schwartz

   Pages 106-129

8. ‘Benign’ myopathies of childhood

   • Michael Swash, Martin S. Schwartz

   Pages 130-147

9. Metabolic, endocrine and drug-induced myopathies

   • Michael Swash, Martin S. Schwartz

   Pages 148-176

10. Neurogenic disorders

    • Michael Swash, Martin S. Schwartz

    Pages 177-197

11. Tumours of striated muscle and related disorders

    • Michael Swash, Martin S. Schwartz

    Pages 198-224

12. Interpretation of the muscle biopsy

    • Michael Swash, Martin S. Schwartz

    Pages 225-231

13. Back Matter

    Pages 232-237

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Museie biopsy is a long-established technique in clinical practice having been introduced by Duchenne in 1868 (Arch. Gen. Med. , 11, 5-179). However, the needle method used by Duchenne was not generally adopted, although Shank and Hoagland described a similar technique in 1943 (Science, 98, 592), and open muscle biopsy has for long been preferred in clinical practice, even with the advent of newer needle biopsy methods (Bergstrom, 1962, Scand. J. Clin. Lab. Invest. , 14, Suppl. 68, 1-110). The development of enzyme histochemical techniques has contributed greatly to knowledge of muscle pathology. More recently electron microscopy and immunocytochemistry have also been applied to clinical diagnosis of neuromuscular disease. This book is intended to serve as a practical guide in muscle pathology, particularly for histopathologists, and for those in training. As enzyme histochemistry has become more widely available, formalin-fixed methods have become less frequently used in muscle biopsy work. In this new edition of Muscle Biopsy Pathology we have taken account of the advances in classification and histological technique, and in knowledge of neuromuscular diseases, that have emerged since the first editionwas published in 1984. We hope that this book will continue to be used as a practical guide in the diagnosis and understanding of these disorders. 1. Introduction 1. 1 Generalfeatures of muscle The differentiation of musde into red and white types is a feature of all vertebrates and, indeed, of chordates.

• biopsy
• electron microscopy
• pathology
• training

• The Royal London Hospital, UK

  Michael Swash

• St Mark’s Hospital London, UK

  Michael Swash

• The Medical College of the Royal London Hospital, UK

  Michael Swash

• St George’s Hospital (Atkinson Morley’s Hospital) London, UK

  Martin S. Schwartz

Policies and ethics