Central D1 Dopamine Receptors

1. Front Matter

   Pages i-viii

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2. Dopamine-Regulated Protein Phosphorylation in the Basal Ganglia

   • Charles C. Ouimet, Hugh C. Hemmings Jr., Paul Greengard

   Pages 1-17

3. The D-1 Dopamine Receptor

   • John W. Kebabian

   Pages 19-31

4. Biochemical Properties of D1 and D2 Dopamine Receptors

   • Susan E. Senogles, Nourdine Amlaiky, Joel G. Berger, Marc G. Caron

   Pages 33-41

5. Biochemical and Functional Characterization of Central Dopamine Receptors

   • Menek Goldstein, Jow Y. Lew, Emanuel Meller

   Pages 43-53

6. Dopamine D1 and D2 Receptor Selectivities of Agonists and Antagonists

   • Philip Seeman, Carla Ulpian

   Pages 55-63

7. DARPP-32 as a Marker for D-1 Dopaminoceptive Cells in the Rat Brain: Prenatal Development and Presence in Glial Elements (Tanycytes) in the Basal Hypothalamus

   • T. Hökfelt, G. Foster, M. Schultzberg, B. Meister, M. Schalling, M. Goldstein et al.

   Pages 65-82

8. Studies on Central D1 Receptors Role in Volume Transmission, Neuroendocrine Regulation and Release of Noradrenaline

   • K. Fuxe, L. F. Agnati, A. Cintra, K. Andersson, P. Eneroth, A. Härfstrand et al.

   Pages 83-119

9. N-Ethoxycarbonyl-2-Ethoxy-1, 2-Dihydroquinoline (EEDQ): A New Tool to Probe CNS Receptor Function

   • Emanuel Meller, Menek Goldstein, Arnold J. Friedhoff, Jack W. Schweitzer

   Pages 121-136

10. Pharmacological and Behavioral Effects of D1 Dopamine Antagonists

    • Allen Barnett, Louis C. Iorio, Robert McQuade, Richard E. Chipkin

    Pages 137-144

11. Neurophysiological Examination of the Role of D-1 Dopamine Receptors in the Regulation of Neuronal Activity in the Basal Ganglia

    • Judith R. Walters, Joanne H. Carlson, Barton G. Weick, Debra A. Bergstrom

    Pages 145-158

12. Diminished D2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements

    • H. Rosengarten, J. W. Schweitzer, M. Egawa, A. J. Friedhoff

    Pages 159-167

13. D-1 Dopamine Receptors and Arousal

    • Ennio Ongini

    Pages 169-178

14. Back Matter

    Pages 179-183

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The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.

• biochemistry
• interaction
• interdependence
• media
• physiology
• proteins
• regulation

• New York University Medical Center, New York, USA

  Menek Goldstein

• Karolinska Institute, Stockholm, Sweden

  Kjell Fuxe

• Schering Corporation, Bloomfield, USA

  Irving Tabachnick

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