Skip to main content
SpringerLink
Log in

Central D1 Dopamine Receptors

  • Book
  • © 1988

Overview

Editors:
  1. Menek Goldstein

    1. New York University Medical Center, New York, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Kjell Fuxe

    1. Karolinska Institute, Stockholm, Sweden

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Irving Tabachnick

    1. Schering Corporation, Bloomfield, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 235)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Dopamine-Regulated Protein Phosphorylation in the Basal Ganglia

    • Charles C. Ouimet, Hugh C. Hemmings Jr., Paul Greengard
    Pages 1-17

  3. The D-1 Dopamine Receptor

    • John W. Kebabian
    Pages 19-31

  4. Biochemical Properties of D1 and D2 Dopamine Receptors

    • Susan E. Senogles, Nourdine Amlaiky, Joel G. Berger, Marc G. Caron
    Pages 33-41

  5. Biochemical and Functional Characterization of Central Dopamine Receptors

    • Menek Goldstein, Jow Y. Lew, Emanuel Meller
    Pages 43-53

  6. Dopamine D1 and D2 Receptor Selectivities of Agonists and Antagonists

    • Philip Seeman, Carla Ulpian
    Pages 55-63

  7. DARPP-32 as a Marker for D-1 Dopaminoceptive Cells in the Rat Brain: Prenatal Development and Presence in Glial Elements (Tanycytes) in the Basal Hypothalamus

    • T. Hökfelt, G. Foster, M. Schultzberg, B. Meister, M. Schalling, M. Goldstein et al.
    Pages 65-82

  8. Studies on Central D1 Receptors Role in Volume Transmission, Neuroendocrine Regulation and Release of Noradrenaline

    • K. Fuxe, L. F. Agnati, A. Cintra, K. Andersson, P. Eneroth, A. Härfstrand et al.
    Pages 83-119

  9. N-Ethoxycarbonyl-2-Ethoxy-1, 2-Dihydroquinoline (EEDQ): A New Tool to Probe CNS Receptor Function

    • Emanuel Meller, Menek Goldstein, Arnold J. Friedhoff, Jack W. Schweitzer
    Pages 121-136

  10. Pharmacological and Behavioral Effects of D1 Dopamine Antagonists

    • Allen Barnett, Louis C. Iorio, Robert McQuade, Richard E. Chipkin
    Pages 137-144

  11. Neurophysiological Examination of the Role of D-1 Dopamine Receptors in the Regulation of Neuronal Activity in the Basal Ganglia

    • Judith R. Walters, Joanne H. Carlson, Barton G. Weick, Debra A. Bergstrom
    Pages 145-158

  12. Diminished D2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements

    • H. Rosengarten, J. W. Schweitzer, M. Egawa, A. J. Friedhoff
    Pages 159-167

  13. D-1 Dopamine Receptors and Arousal

    • Ennio Ongini
    Pages 169-178

  14. Back Matter

    Pages 179-183
    Download chapter PDF
Back to top

Keywords

About this book

The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.

Editors and Affiliations

  • New York University Medical Center, New York, USA

    Menek Goldstein

  • Karolinska Institute, Stockholm, Sweden

    Kjell Fuxe

  • Schering Corporation, Bloomfield, USA

    Irving Tabachnick

Bibliographic Information

  • Book Title: Central D1 Dopamine Receptors

  • Editors: Menek Goldstein, Kjell Fuxe, Irving Tabachnick

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4899-2723-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1988

  • Softcover ISBN: 978-1-4899-2725-5Published: 07 June 2013

  • eBook ISBN: 978-1-4899-2723-1Published: 21 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 183

  • Number of Illustrations: 26 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

Publish with us

Policies and ethics

Back to top

Search

Navigation