The Enzymes of Biological Membranes

1. Front Matter

   Pages i-xv

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2. Electron Transport and Phosphorylation

   1. Front Matter

      Pages 1-1

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   2. The Enzymes and the Enzyme Complexes of the Mitochondrial Oxidative Phosphorylation System

      • Youssef Hatefi

      Pages 3-41

   3. Cytochrome c, A Membrane-Bound Enzyme

      • Jane Vanderkooi, Maria Erecińska

      Pages 43-86

   4. The Structure of Cytochrome Oxidase

      • Roderick A. Capaldi, Margaret Briggs

      Pages 87-102

   5. The Adenosine Triphosphatase Complex of Mitochondria

      • Alexander Tzagoloff

      Pages 103-124

   6. Reconstitution of the Inner Mitochondrial Membrane

      • Yasuo Kagawa

      Pages 125-142

   7. Cytochrome b ₅ and Cytochrome b ₅ Reductase from a Chemical and X-Ray Diffraction Viewpoint

      • F. Scott Mathews, Edmund W. Czerwinski

      Pages 143-197

   8. On The Structure and Function of Cytochromes P-450

      • Karl Dus

      Pages 199-238

   9. Enzyme-Generated Free Radicals as Initiators of Lipid Peroxidation in Biological Membranes

      • Paul B. McCay, J. Lee Poyer

      Pages 239-256

3. Receptors

   1. Front Matter

      Pages 257-257

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   2. Adenylate Cyclase: General Properties and Role of Phospholipids in Hormone Activation

      • Gerald S. Levey, Denis C. Lehotay

      Pages 259-282

   3. Membrane-Bound Hormone Receptors

      • Robert J. Lefkowitz, Marc G. Caron, Lee Limbird, Chhabirani Mukherjee, Lewis T. Williams

      Pages 283-310

   4. Acetylcholine Receptors: Approaches to the Mechanism of Permeability Control

      • Arthur Karlin

      Pages 311-330

   5. Acetylcholinesterase

      • Terrone L. Rosenberry

      Pages 331-363

   6. Rhodopsin in Cell Membranes and the Process of Phototransduction

      • M. Montal, J. I. Korenbrot

      Pages 365-405

4. Back Matter

   Pages 407-431

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For a long time membrane biochemistry was almost synonymous with the bio­ chemistry of electron transport and oxidative phosphorylation. Although the successful analysis of hormone receptors, active transport, and other membrane-linked metabolic systems displaced mitochondria from the focus of interest, the field continued to grow and its contributions to other areas of membrane biochemistry played a major role in their dramatic development. The eight chapters in this volume dealing with electron transport provide a concise, critical, and up-to-date picture of the problems and accomplishments of the field. In the remainder of the volume a brief summary of selected receptor functions is presented. The relative novelty of this field naturally limits the factual scope of developments and encourages speculation. Nevertheless these reviews accurately reflect both accomplishments and deficiencies and provide objective guidance for future development. Several receptor functions omitted from these discussions will form one of the later volumes currently in preparation.

• biochemistry
• chemistry
• enzymes
• mitochondria
• phosphorylation
• receptor

• Department of Biochemistry, School of Medicine, Saint Louis University, St. Louis, USA

  Anthony N. Martonosi

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