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Purine and Pyrimidine Metabolism in Man VII

Part A: Chemotherapy, ATP Depletion, and Gout

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  • © 1991

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Editors:
  1. R. Angus Harkness

    1. Institute of Child Health, London, UK

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  2. Gertrude B. Elion

    1. Burroughs Wellcome Co., Research Triangle Park, USA

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  3. Nepomuk Zöllner

    1. Universität München, München, Germany

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 309A)

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Table of contents (106 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. Chemotherapy

    1. Historical Development

      1. Biochemical Approach to New Medications
        • George H. Hitchings
        Pages 1-6

    2. Cancer and AIDS Treatment

      1. Antimetabolites in Cancer Chemotherapy
        • Stephen J. Clarke, Ann L. Jackman, Kenneth R. Harrap
        Pages 7-13
      2. 2-Chlorodeoxyadenosine Chemotherapy Triggers Programmed Cell Death in Normal and Malignant Lymphocytes
        • Carlos J. Carrera, Lawrence D. Piro, Alan Saven, Ernest Beutler, Chihiro Terai, Dennis A. Carson
        Pages 15-18
      3. ICI D1694, An Inhibitor of Thymidylate Synthase for Clinical Study
        • Ann L. Jackman, Duncan I. Jodrell, William Gibson, Trevor C. Stephens
        Pages 19-23
      4. Action and Sequence Dependent Interaction of Acivicin and 6-Thioguanine in Human Derived Malignant T-All and Calla+ Cell Lines
        • R. C. Trueworthy, R. A. DeAbreu, L. H. J. Lambooy, J. P. M. Bökkerink, E. H. Stet
        Pages 25-28
      5. Conversion of Acyclic Nucleoside Phosphonates to Their Diphosphate Derivatives by 5-Phosphoribosyl-1-Pyrophosphate (PRPP) Synthetase
        • J. Balzarini, E. de Clercq
        Pages 29-32
      6. Derivation of New Drugs for Therapy of Aids
        • Kenneth L. Powell, Dorothy J. Purifoy
        Pages 33-40

    3. Development and Effects of New Analogues

      1. Biochemical and Pharmacological Properties of CI-972, a Novel 9-Deazaguanine Analog Purine Nucleoside Phosphorylase (PNP) Inhibitor
        • Richard B. Gilbertsen, Mi K. Dong, David J. Wilburn, Lynn M. Kossarek, Jagadish C. Sircar, Catherine R. Kostlan et al.
        Pages 41-44
      2. Pyrrolo[3,2-D]Pyrimidines, a New Class of Purine Nucleoside Phosphorylase (PNP) Inhibitors as Potential T-Cell Selective Immunosuppressive Agents
        • J. C. Sircar, C. R. Kostlan, R. B. Gilbertsen, M. K. Dong, W. A. Cetenko
        Pages 45-48
      3. Modulation of Metabolism and Anti-HIV-1 Activity of Purine 2′,3′-Dideoxynucleosides by IMP Dehydrogenase Inhibitors
        • Larry L. Bondoc Jr., Brian L. Robbins, Gurpreet S. Ahluwalia, Hiroaki Mitsuya, David G. Johns, Arnold Fridland
        Pages 49-53
      4. Acadesine (AICA Riboside) Inhibits Platelet Aggregation in Human Whole Blood
        • D. A. Bullough, C. Zhang, K. M. Mullane
        Pages 55-55
      5. Concentration and Time Dependent Growth Inhibition and Metabolism <u>in vitro</u> by 2’,2’-Difluoro-Deoxycytidine (Gemcitabine)
        • Veronique W. T. Ruiz van Haperen, Gijsbert Veerman, Paul Noordhuis, Jan B. Vermorken, Godefridus J. Peters
        Pages 57-60

    4. Analogue Effects and Metabolism

      1. Thiopurine Methyltransferase Activity and Efficacy of Azathioprine Immunosuppression in Transplant Recipients
        • Pedro R. Chocair, John A. Duley, H. Anne Simmonds, J. Stewart Cameron
        Pages 61-64
      2. Increase in 2’,5’-Oligoadenylate Synthetase Caused by Deoxycoformycin in Hairy Cell Leukaemia
        • K. Ganeshaguru, W. C. P. de Mel, G. Sissolak, D. Catovsky, C. E. Dearden, A. B. Mehta et al.
        Pages 65-68
      3. A Dual Anti-Tumor Effect of a Combination of Interferon-α and 5-Flurouracil or 2-Chlorodeoxyadenosine on Natural Killer (NK) Cell Mediated Cytotoxicity
        • Zvi Reiter, Osman N. Ozes, Sue Tomson, Lawrence M. Blatt, Milton W. Taylor
        Pages 69-73
      4. The Effect of Methotrexate on the Folate Coenzyme Pools in Human Hepatoma Cells in Culture
        • John Galivan, Myung Rhee, David G. Priest, Marlene Bunni, James H. Freisheim, John M. Whiteley
        Pages 75-78
      5. Purine Nucleotide Biosynthesis in Leukemic Promyelocytes Treated with Retinoids
        • Hiroshi Tsutani, Daizaburo Kagawa, Michihiko Uchida, Teruo Yoshimura, Tsuneo Tanaka, Takanori Ueda et al.
        Pages 79-82
      6. 6-Mercaptopurine Metabolism in Two Leukemic Cell Lines
        • E. H. Stet, R. A. De Abreu, Y. P. G. Janssen, J. P. M. Bökkerink, J. M. F. Trijbels
        Pages 83-86
      7. Synergistic Interaction of Methotrexate and 6-Mercaptopurine in Human Derived Malignant T-All and Calla+ Cell Lines
        • Ronney A. De Abreu, Frank van Strien, Lambert H. J. Lambooy, J. P. M. Bökkerink
        Pages 87-91
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Keywords

About this book

These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European society for the Study of Purine and Pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in Switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in vii rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.

Editors and Affiliations

  • Institute of Child Health, London, UK

    R. Angus Harkness

  • Burroughs Wellcome Co., Research Triangle Park, USA

    Gertrude B. Elion

  • Universität München, München, Germany

    Nepomuk Zöllner

Bibliographic Information

  • Book Title: Purine and Pyrimidine Metabolism in Man VII

  • Book Subtitle: Part A: Chemotherapy, ATP Depletion, and Gout

  • Editors: R. Angus Harkness, Gertrude B. Elion, Nepomuk Zöllner

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4899-2638-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Hardcover ISBN: 978-0-306-44092-2Published: 31 December 1991

  • Softcover ISBN: 978-1-4899-2640-1Published: 18 July 2013

  • eBook ISBN: 978-1-4899-2638-8Published: 11 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXII, 474

  • Topics: Biochemistry, general

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