Molecular Basis of Human Cancer

1. Front Matter

   Pages i-viii

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2. Cell Structure and the Regulation of Genes Controlling Proliferation and Differentiation: The Nuclear Matrix and Cytoskeleton

   • Gary S. Stein, Jane B. Lian, Thomas A. Owen, Janet L. Stein, Melissa Tassinari, Andre van Wijnen et al.

   Pages 1-38

3. Cell Structure and Gene Expression: Contributions of the Extracellular Matrix to Regulation of Osteoblast Growth and Differentiation

   • Jane B. Lian, Gary S. Stein, Thomas A. Owen, Michael Aronow, Melissa S. Tassinari, Shirwin Pockwinse et al.

   Pages 39-71

4. The Beginning of a Molecular Description of Human Cancer: Chromatin 3D-Structure, DNA Supercoil, H1 Histone, Microtubules and the Modulation of Unbalanced Gene Expression

   • C. Nicolini

   Pages 73-99

5. Problems in Understanding the Organization, Structure and Function of Chromosomes

   • E. Morton Bradbury

   Pages 101-113

6. Expression of C-MYC, C-FOS and C-JUN Proto-Oncogenes During Muscle Differentiation in Vitro

   • Nils Ringertz, Magnus Rahm, Anna Hultgardh-Nilsson, Pei Jin, Thomas Sejersen

   Pages 115-126

7. The Expression and Regulation of PP90RSK, a Highly Conserved Mitogen-Responsive Serine-Specific Protein Kinase

   • R. L. Erikson, David A. Alcorta, Eleanor Erikson, Laurel J. Sweet, Terry A. Vik

   Pages 127-141

8. Molecular Biology of Leukemias and Lymphomas

   • Carlo M. Croce, Charlotte E. Gauwerky

   Pages 143-161

9. Recessive Mutations in Human Cancer Progression

   • Webster K. Cavenee

   Pages 163-171

10. Transforming Growth Factor-β Regulation of Epithelial Proliferation

    • Jennifer A. Pietenpol, Edmund Y. Yang, Harold L. Moses

    Pages 173-182

11. b-N-Acetylhexosaminidase in Leukaemic Cells

    • Carla Emiliani, Sabata Martino, John L. Stirling, Aldo Orlacchio

    Pages 183-193

12. The Role of Small t Antigen in SV40 Oncogenesis

    • M. Carbone, F. Pompetti, C. Cicala, P. Nguyen, K. Dixon, A. S. Levine

    Pages 195-206

13. Back Matter

    Pages 207-216

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During May 21-June 1 1990, the eleventh course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the Italian Ministry of Universities and of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and Technobiochip. The subject of the course was "Molecular Basis of Human Cancer" with participants selected worldwide from 15 different countries. The purpose of the course was to address, in a tutorial and structural fashion, the molecular basis of human cancer, including the mechanism of signal transduction in mammalian cells, the genetic mechanism of malignant transformation in man, growth factors, hormone receptors, cell membrane and cytoskeleton, and DNA high order structure. The course had this as its major objective and the resulting book reflects it. The participants were exposed to a critical evaluation of current knowledge about cancer and to some of the key problems that remain as stumbling blocks to our eventual understanding of this important biological and medical problem. Through the media of formal and informal lectures, workshops, symposia and informal discussions, a select group of interested young and senior scientists were acquainted with many of the aspects of human cancer.

• Chromosom
• DNA
• Mammalia
• gene expression
• genes
• molecular biology
• signal transduction

• University of Genoa, Genoa, Italy

  Claudio Nicolini

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