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Heparin and Related Polysaccharides

  • Book
  • © 1992

Overview

Editors:
  1. David A. Lane

    1. Charing Cross and Westminster Medical School, London, UK

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  2. Ingemar Björk

    1. The Swedish University of Agricultural Sciences, Uppsala, Sweden

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  3. Ulf Lindahl

    1. Uppsala University, Uppsala, Sweden

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 313)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Historical Aspects

    1. Heparin — an Introduction

      • Lennart Rodén, Sandya Ananth, Patrick Campbell, Tracy Curenton, Göran Ekborg, Stephen Manzella et al.
      Pages 1-20

  3. Structural Properties of Heparin and Heparan Sulphate

    1. Chemical Synthesis and Hemisynthesis in the Field of Glycosaminoglycans

      • Maurice Petitou
      Pages 21-30

    2. Structural Analysis of Periodate-Oxidized Heparin

      • H. Edward Conrad, Yuchuan Guo
      Pages 31-36

    3. New Methodologies in Heparin Structure Analysis and the Generation of LMW Heparins

      • Robert J. Linhardt, Hui-ming Wang, Stephen A. Ampofo
      Pages 37-47

    4. Heparan Sulphate Proteoglycans: Molecular Organisation of Membrane-Associated Species and an Approach to Polysaccharide Sequence Analysis

      • John T. Gallagher, Jeremy E. Turnbull, Malcolm Lyon
      Pages 49-57

  5. Heparin and Heparan Sulphate Proteoglycansinteractions and Metabolism

    1. Animal Cell Mutants Defective in Heparan Sulfate Polymerization

      • Jeffrey D. Esko
      Pages 97-106

    2. Two Enzymes in One: N-Deacetylation and N-Sulfation in Heparin Biosynthesis are Catalyzed by the Same Protein

      • Lena Kjellén, Inger Pettersson, Erik Unger, Ulf Lindahl
      Pages 107-111

    3. Metabolism of Plasma Membrane-Associated Heparan Sulfate Proteoglycans

      • Masaki Yanagishita
      Pages 113-120

    4. Lysosomal Degradation of Heparin and Heparan Sulphate

      • Craig Freeman, John Hopwood
      Pages 121-134

    5. Heparin Binding Properties of the Carboxyl Terminal Domain of [A103,106,108] Antistasin 93–119

      • George D. Manley, Thomas J. Owen, John L. Krstenansky, Robert G. Brankamp, Alan D. Cardin
      Pages 135-140

    6. Heparin Protein Interactions

      • Fanyu Zhou, Teresia Höök, John A. Thompson, Magnus Höök
      Pages 141-153

  6. Anticoagulant Proteins

    1. Role of Protein Conformational Changes, Surface Approximation and Protein Cofactors in Heparin-Accelerated Antithrombin-Proteinase Reactions

      • Steven T. Olson, Ingemar Björk
      Pages 155-165

    2. The Interaction of Glycosaminoglycans with Heparin Cofactor II: Structure and Activity of a High-Affinity Dermatan Sulfate Hexasaccharide

      • Douglas M. Tollefsen
      Pages 167-176

    3. Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety

      • John F. Parkinson, Takatoshi Koyama, Nils U. Bang, Klaus T. Preissner
      Pages 177-188

    4. The Interaction Between LACI and Heparin

      • George J. Broze Jr., Robin Wesselschmidt, Darryl Higuchi, Thomas Girard, Karen Likert, Louise MacPhail et al.
      Pages 189-197
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Keywords

About this book

This volume is a record of a meeting entitled "Heparin and Related Polysaccharides" that was held at the Biomedical Center, Uppsala, Sweden between 1-6 September 1991. The meeting was hosted by U. Lindahl, L. Kjellen and I. Bjork, who were helped in their preparations by a scientific advisory panel that included U. Abildgaard, B. Casu, E. Holmer and D. Lane. Altogether, 230 participants from 18 countries attended the meeting, and most were present to be included in a photograph, which is to be found at the end of this volume. The selection of presentations for inclusion in the Symposia of the meeting was made on the basis of the known high quality of the work of the individuals or groups involved. This, we believe, is reflected in the contents of the enclosed articles, which collectively give a comprehensive overview of the present state of knowledge of heparin and related compounds. Some of the areas covered are evolving or controversial and the views expressed in each article should be regarded as those of the author(s). The authors have taken various amounts of care to define all their abbreviations and some familiarity with the different forms of nomenclature used in the fields of polysaccharide chemistry and of the coagulation proteinases and their inhibitors will assist the reader.

Editors and Affiliations

  • Charing Cross and Westminster Medical School, London, UK

    David A. Lane

  • The Swedish University of Agricultural Sciences, Uppsala, Sweden

    Ingemar Björk

  • Uppsala University, Uppsala, Sweden

    Ulf Lindahl

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