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Polymeric Materials in Medication

  • Book
  • © 1985

Overview

Editors:
  1. Charles G. Gebelein

    1. Youngstown State University, Youngstown, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Charles E. Carraher

    1. Florida Atlantic University, Boca Raton, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Polymer Science and Technology Series (POLS, volume 32)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Methodologies in Polymeric Medication

    • Charles G. Gebelein
    Pages 1-9

  3. Tissue/Material Interactions of Biomedical Polymers

    • R. E. Marchant, J. M. Anderson
    Pages 11-26

  4. Polymer-Controlled Drug Delivery Systems: Science and Engineering

    • Yie W. Chien
    Pages 27-46

  5. Fibrous Delivery Systems for Antimicrobial Agents

    • R. L. Dunn, J. W. Gibson, B. H. Perkins, J. Max Goodson, L. E. Laufe
    Pages 47-59

  6. Evaluation of Membrane Suitability in Transdermal Drug Delivery

    • James L. Gaskill, Pramod P. Sarpotdar, Robert P. Giannini
    Pages 61-71

  7. Diffusion Controlled Release of Drugs from Coated Drug Polymer Complex

    • Y. Raghunathan, L. Amsel, O. Hinsvark, K. Rotenberg
    Pages 73-78

  8. Kinetics of Drug Release from Glassy Polymers: Effect of Initially Nonuniform Drug Distribution

    • Ping I. Lee
    Pages 79-85

  9. The Role of Polymer Matrix Structure and Interparticle Interaction in Diffusion-Limited Drug Release

    • Anna C. Balazs, Daniel F. Calef, J. M. Deutch, Ronald A. Siegel, Robert Langer
    Pages 87-101

  10. Polymeric Anticancer Agents — An Overview

    • Malay Ghosh, Sukumar Maiti
    Pages 103-114

  11. The Controlled Release of 5-Fluorouracil from Acrylate Copolymers of 1-(N-2-Ethylmethacrylcarbamoyl)-5-Fluorouracil Monomer

    • Robert R. Hartsough, Charles G. Gebelein
    Pages 115-124

  12. Halogenated Nucleic Acids: Biochemical and Biological Properties of Fluorinated Polynucleotides

    • J. L. Alderfer, R. E. Loomis, S. D. Soni, M. Sharma, R. Bernacki, R. Hughes Jr.
    Pages 125-138

  13. Toxicity and Tissue Distribution of MVE-2 in the Dog After Intravenous and Intraperitonal Administration

    • J. R. Baldwin, R. A. Carrano, A. R. Imondi, J. D. Iuliucci, L. M. Hagerman
    Pages 139-149

  14. Transformation of Mouse Fibroblast (T3T) Cells Employing the Oncogenic Simian Virus 40 (SV40) for Evaluation of Anticancer Compounds

    • David J. Giron, Mark J. Espy, Charles E. Carraher Jr.
    Pages 151-163

  15. Screening of Platinum II Polymines as Antitumor Drugs Employing Cell Differation of Normal and Transformed 3T3 Cells

    • David J. Giron, Mark J. Espy, Charles E. Carraher Jr., Isabel Lopez
    Pages 165-171

  16. Polymeric Derivatives of cis-Dichlorodiammineplatinum II Analogs Based on Polyvinylamine-co-vinylsulfonate as Model Carriers in the Drug Delivery System

    • Charles E. Carraher Jr., Claredine M. Ademu-John, John J. Fortman, David J. Giron, Carolyn Turner, Raymond Linville
    Pages 173-181

  17. Soluble Excipients Assisting Dissolution of Drugs: Importance of Amorphous State

    • Josef Pitha
    Pages 183-190

  18. Polymeric Hydroxamic Acids for Iron Chelators Therapy

    • A. Winston, D. V. P. R. Varaprasad, J. J. Metterville, H. Rosenkrantz
    Pages 191-196

  19. Oxygen Species Chemistry of Osmium Carbohydrate Polymers

    • C. C. Hinckley, M. A. Islam, P. A. Kibala, J. L. Skosey, D. C. Chow, S. Liu
    Pages 197-210

  20. Synthetic Polymeric Inducers of Interferon

    • Ernest M. Hodnett
    Pages 211-226
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Keywords

About this book

The art of using chemical agents for medication dates back into antiquity, although most of the earliest examples used plants, herbs, and other natural materials. The old Egyptian medical papyri, which date from before 1400 B. C. , contain dozens of examples of such medicinal plants and animal extracts. In the Old Testament of the Bible, we can find references to using oil to soften the skin and sores (Isaiah 1:6), the use of tree leaves for medicine (Ezekiel 47:12) and various medical balms (Jeremiah 8:22). Not all these recipes were effective in curing the ailments for which they were used and sometimes the treatment was worse than the disease. Nevertheless, the art of using chemical derived agents for medicines continued to develop and received great impetus during the present century with the rise of synthetic organic chemistry. One of the most vexing problems has always been to achieve specifici­ ty with the medications. While some medical agents do indeed possess a relatively high degree of specificity, most agents are far more systemic than would be desired. Much of the research efforts to correct this deficiency has centered on modifying the chemical agents themselves. Unfortunately, there are severe limitations in this approach since minor modifications often drastically affect the therapeutic activity and can even render the drug completely ineffective, or worse.

Editors and Affiliations

  • Youngstown State University, Youngstown, USA

    Charles G. Gebelein

  • Florida Atlantic University, Boca Raton, USA

    Charles E. Carraher

Bibliographic Information

  • Book Title: Polymeric Materials in Medication

  • Editors: Charles G. Gebelein, Charles E. Carraher

  • Series Title: Polymer Science and Technology Series

  • DOI: https://doi.org/10.1007/978-1-4899-2245-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1985

  • Hardcover ISBN: 978-0-306-42115-0Published: 01 January 1986

  • Softcover ISBN: 978-1-4899-2247-2Published: 29 June 2013

  • eBook ISBN: 978-1-4899-2245-8Published: 11 November 2013

  • Series ISSN: 0093-6286

  • Edition Number: 1

  • Number of Pages: VIII, 302

  • Topics: Physics, general

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