Molecular Biology of Aging

1. Front Matter

   Pages i-xiv

   PDF

2. Symposium Lecture - I

   1. Aging Research: Challenge of the Twenty-First Century

      • E. L. Schneider

      Pages 1-11

3. Wear and Tear Hypotheses

   1. Introductory Remarks, Session II

      • J. R. Totter

      Pages 13-14

   2. Antioxidants and Longevity of Mammalian Species

      • Richard G. Cutler

      Pages 15-73

   3. Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

      • R. S. Sohal, R. G. Allen

      Pages 75-104

   4. State of Knowledge on Action of Food Restriction and Aging

      • Edward Masoro

      Pages 105-116

   5. The Endocrine Response to Dietary Restriction in the Rat

      • B. J. Merry, Anne M. Holehan

      Pages 117-141

   6. Age Dependent Changes in Mitochondria

      • J. E. Fleming, J. Miquel, K. G. Bensch

      Pages 143-156

4. Aging in Cellular Proteins

   1. Introductory Remarks—With Consideration of a T-Cell Model for Aging in Cellular Proteins

      • Takashi Makinodan, Timothy C. Fong, Tsutomu Inamizu, Mei-Ping Chang

      Pages 157-162

   2. Implications of 5′-Nucleotidase and its Inhibitor for Cellular Aging and Cancer

      • Alexander S. Sun, James F. Holland

      Pages 163-180

   3. The Effects of Dehydroepiandrosterone on the Rate of Development of Cancer and Autoimmune Processes in Laboratory Rodents

      • Arthur Schwartz

      Pages 181-191

   4. The Alteration of Enzymes in Aging Animals

      • Morton Rothstein

      Pages 193-204

   5. Differential and Similar Responses Between Rodent and Human Cells to DNA-Damaging Agents: Possible Implications for Cellular Aging

      • Jerry R. Williams, Peter D’Arpa, John Opishinski, Larry Dillehay, David Jacobson-Kram

      Pages 205-211

5. Symposium Lecture - II

   1. Living All Your Life

      • Alex Comfort

      Pages 213-229

6. Changes in DNA with Age - I

   1. Environmental and Genetic Factors that Influence Immunity and Longevity in Mice

      • D. J. Anderson, A. L. M. Watson, E. J. Yunis

      Pages 231-240

   2. Cellular Senescence: Factors Modulating Cell Proliferation In Vitro

      • Vincent J. Cristofalo, Paul D. Phillips, Katherine M. Brooks

      Pages 241-253

   3. Changes in Genetic Organization and Expression in Aging Cells

      • Samuel Goldstein, Arun Srivastava, Karl T. Riabowol, Robert J. Shmookler Reis

      Pages 255-267

7. Changes in DNA with Age - II

   1. The Significance of DNA Methylation in Cellular Aging

      • Robin Holliday

      Pages 269-283

   2. DNA Manipulating Genes and the Aging Brain

      • Chev Kidson, Philip Chen, F. Paula Imray

      Pages 285-296

   3. In Vivo Studies on DNA Repair and Turnover with Age

      • Takatoshi Ishikawa, Junko Sakurai, Shozo Takayama

      Pages 297-313

It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore­ gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.

• DNA
• DNA repair
• aging
• biology
• brain
• cancer
• development
• enzymes
• immunity
• mitochondria
• molecular biology
• planning
• proliferation
• protein

• Brookhaven National Laboratory, Upton, USA

  Avril D. Woodhead

• University of Manchester Institute of Science and Technology, Manchester, UK

  Anthony D. Blackett

• Council for Research Planning in Biological Sciences, Inc., USA

  Alexander Hollaender

Policies and ethics