Insecticide Biochemistry and Physiology

1. Front Matter

   Pages i-xxii

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2. Penetration and Distribution

   1. Front Matter

      Pages 1-1

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   2. Penetration and Distribution of Insecticides

      • Gerald Thomas Brooks

      Pages 3-58

3. Metabolism

   1. Front Matter

      Pages 59-59

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   2. Microsomal Oxidation and Insecticide Metabolism

      • Tsutomu Nakatsugawa, Michael A. Morelli

      Pages 61-114

   3. Cytochrome P450 Interactions

      • Ernest Hodgson, Laurence G. Tate

      Pages 115-148

   4. Extramicrosomal Metabolism of Insecticides

      • W. C. Dauterman

      Pages 149-176

   5. Enzymatic Conjugation and Insecticide Metabolism

      • Raymond S. H. Yang

      Pages 177-225

4. Target Site Interactions

   1. Front Matter

      Pages 227-227

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   2. The Nervous System: Comparative Physiology and Pharmacology

      • D. L. Shankland

      Pages 229-270

   3. Acetylcholinesterase and Its Inhibition

      • R. D. O’Brien

      Pages 271-296

   4. The Acetylcholine Receptor and Its Interactions with Insecticides

      • Amira Toppozada Eldefrawi

      Pages 297-326

   5. Effects of Insecticides on Nervous Conduction and Synaptic Transmission

      • Toshio Narahashi

      Pages 327-352

   6. Insecticides as Inhibitors of Respiration

      • Jun-ichi Fukami

      Pages 353-396

   7. Physicochemical Aspects of Insecticidal Action

      • T. R. Fukuto

      Pages 397-428

5. Selectivity and Resistance

   1. Front Matter

      Pages 429-429

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   2. The Biochemical and Physiological Basis of Selective Toxicity

      • R. M. Hollingworth

      Pages 431-506

   3. Biochemistry and Physiology of Resistance

      • F. J. Oppenoorth, W. Welling

      Pages 507-551

6. Insecticide Toxicology

   1. Front Matter

      Pages 553-553

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   2. Teratogenic, Mutagenic, and Carcinogenic Effects of Insecticides

      • Lawrence Fishbein

      Pages 555-603

Only four short decades ago, the control of insect pests by means of chemicals was in its early infancy. The pioneers in the area consisted largely of a group of dedicated applied entomologists working to the best of their abilities with a very limited arsenal of chemicals that included inorganics (arsenicals, fluorides, etc.), some botanicals (nicotine), and a few synthetic organics (dinitro-o-cresol, organothiocyanates). Much of the early research was devoted to solving practical problems associated with the formulation and application of the few existing materials, and although the discovery of new types of insecticidal chemicals was undoubtedly a pipe dream in the minds of some, little or no basic research effort was expended in this direction. The discovery of the insecticidal properties of DDT by Paul Miiller in 1939 has to be viewed as the event which marked the birth of modern insecticide chemistry and which has served as the cornerstone for its subse­ quent developement. DDT clearly demonstrated for the first time the dramatic potential of synthetic organic chemicals for insect control and provided the initial stimulus which has caused insecticide chemistry to become a field not only of immense agricultural and public health importance but also one that has had remarkable and unforseeable repercussions in broad areas of the physical, biological, and social sciences. Indeed, there can be few other synthetic chemicals which will be judged in history to have had such a broad and telling impact on mankind as has DDT.

• Oxidation
• biochemistry
• chemistry
• cytochrome P450
• environment
• insect
• metabolism
• nervous system
• pharmacology
• physiology
• receptor
• research
• resistance
• toxicity
• toxicology
• Entomology

• Cornell University, Ithaca, USA

  C. F. Wilkinson

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