Ubiquitin and the Biology of the Cell

1. Front Matter

   Pages i-xxi

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2. The Ubiquitin System

   • Avram Hershko

   Pages 1-17

3. Polyubiquitin Chains

   • Cecile M. Pickart

   Pages 19-63

4. The Ubiquitin-Conjugation System

   • Martin Scheffner, Susan Smith, Stefan Jentsch

   Pages 65-98

5. The Deubiquitinating Enzymes

   • Keith D. Wilkinson, Mark Hochstrasser

   Pages 99-125

6. The 20 S Proteasome

   • Andrei Lupas, Wolfgang Baumeister

   Pages 127-146

7. The 26 S Proteasome

   • Martin Rechsteiner

   Pages 147-189

8. Function of the Proteasome in Antigen Presentation

   • Jochen Beninga, Alfred L. Goldberg

   Pages 191-222

9. The N-End Rule Pathway

   • A. Varshavsky, C. Byrd, I. V. Davydov, R. J. Dohmen, F. Du, M. Ghislain et al.

   Pages 223-278

10. Ubiquitin-Dependent Degradation of Transcription Regulators

    • Mark Hochstrasser, Daniel Kornitzer

    Pages 279-302

11. Role of the Ubiquitin—Proteasome Pathway in NF-κB Activation

    • Zhijian J. Chen, Tom Maniatis

    Pages 303-322

12. Ubiquitination of the p53 Tumor Suppressor

    • Jon M. Huibregtse, Carl G. Maki, Peter M. Howley

    Pages 323-343

13. Cell Cycle Control by Ubiquitin-Dependent Proteolysis

    • Jan-Michael Peters, Randall W. King, Raymond J. Deshaies

    Pages 345-387

14. Ubiquitination of Integral Membrane Proteins and Proteins in the Secretory Pathway

    • Ron R. Kopito

    Pages 389-409

15. Degradation of Ornithine Decarboxylase

    • Philip Coffino

    Pages 411-428

16. Ubiquitin and the Molecular Pathology of Human Disease

    • R. John Mayer, Michael Landon, James Lowe

    Pages 429-462

17. Back Matter

    Pages 463-472

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The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re­ counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.

• biology
• cell biology
• membrane proteins
• protein
• transcription

• Research Institute of Molecular Pathology, Vienna, Austria

  Jan-Michael Peters

• Institute of Zoology, University of Mainz, Mainz, Germany

  J. Robin Harris

• Harvard Medical School, Boston, USA

  Daniel Finley

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