Muscle, Matrix, and Bladder Function

1. Front Matter

   Pages i-ix

   PDF

2. The Clinical Relevance of Basic Science: A Surgeon’s Perspective

   • John W. Duckett

   Pages 1-2

3. Bladder Outlet Obstruction — An Overview

   • Alan J. Wein

   Pages 3-5

4. Bladder Function in Experimental Outlet Obstruction: Pharmacologic Responses to Alterations in Innervation, Energetics, Calcium Mobilization, and Genetics

   • Robert M. Levin, Niels Haugaard, Sheila S. Levin, Ralph Buttyan, Min-Wei Chen, Frederick C. Monson et al.

   Pages 7-19

5. Electrical Properties of Obstructed Guinea Pig Bladder

   • Jacek L. Mostwin, Narihito Seki Omer Karim, Gommert van Koeveringe

   Pages 21-28

6. Metabolism of Detrusor Smooth Muscle in Normal and Obstructed Urinary Bladder

   • Bengt Uvelius, Anders Arner

   Pages 29-39

7. The Neuronal Response to Bladder Outlet Obstruction, a Role for NGF

   • Mary C. Dupont, Katarina Persson, John Spitsbergen, Jeremy B. Tuttle, William D. Steers

   Pages 41-54

8. Contractile Proteins and Their Response to Bladder Outlet Obstruction

   • Samuel Chacko, Penelope A. Longhurst

   Pages 55-63

9. Molecular Aspects of Bladder Outlet Obstruction

   • Victor K. Lin, John D. McConnell

   Pages 65-74

10. Bladder Outlet Obstruction — Discussion

    • Stephen A. Zderic

    Pages 75-79

11. Developmental Physiology-Overview

    • William C. de Groat

    Pages 81-83

12. Fetal Lower Urinary Tract Physiology: In Vivo Studies

    • Robert A. Mevorach, Barry A. Kogan

    Pages 85-91

13. Fetal Bovine Compliance Changes

    • Laurence Baskin, Dave Meaney, Adam Landsman, Serban Constantinescu, Edward Macarak

    Pages 93-104

14. Developmental Aspects of Excitation Contraction Coupling in Urinary Bladder Smooth Muscle

    • Stephen A. Zderic, Chaoliang Gong, Joseph Hypolite, Robert M. Levin

    Pages 105-115

15. Congenital Bladder Obstruction: Research Strategies and Directions

    • Craig A. Peters

    Pages 117-130

16. Developmental Bladder Physiology — Discussion

    • Stephen A. Zderic

    Pages 131-139

17. Extracellular Matrix Update — Overview

    • Gary Striker

    Pages 141-142

18. Is Collagen Remodeling Associated with Bladder Obstruction?

    • H. Paul Ehrlich

    Pages 143-149

19. Regulation of Matrix Metalloproteinases during Extracellular Matrix Turnover

    • Marta L. Corcoran, David E. Kleiner Jr., William G. Stetler-Stevenson

    Pages 151-159

20. Elastic Fibers and Their Role in Bladder Extracellular Matrix

    • Joel Rosenbloom, Harry Koo, Pamela S. Howard, Robert Mecham, Edward J. Macarak

    Pages 161-172

This conference and monograph were the result of many collective efforts. The whole concept was formulated one early Wednesday morning at our weekly research meeting at Children's Hospital in our division of urology. We have been most fortunate to have a close collaboration with Bob Levin, Ed Macarak, and Pam Howard who have helped steer the course of our division's growing interest in basic science. At our weekly meetings our laboratory fellow will summarize their current work. Other ongoing areas of investigation in our labs and elsewhere are discussed. We have always made an effort to try and understand what other groups are doing who are working in the area of bladder smooth muscle research. It occurred to us that the best way to really know what everyone working in this field was doing would be to sponsor a 2-day meeting where we could all gather to discuss our ongoing work. A major limitation of the annual meeting of the American Urologic Association or the urology section of the American Academy of Pediatrics is that the scientfic sessions are limited as these are meant to be primarily clinical meetings (as they should be). For this reason the idea of a meeting devoted solely to research about the urinary bladder had great appeal. In addition to allowing for longer presentations than the standard 5 to 7 minutes, every effort would be made to encourage a dialogue amongst the presenters and the audience.

• development
• genetics
• metabolism
• molecular aspects
• physiology
• smooth muscle
• urology

• School of Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA

  Stephen A. Zderic

Policies and ethics