Taurine in Health and Disease

1. Front Matter

   Pages i-xi

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2. Chemistry, Biochemistry and Metabolism of Taurine

   1. Possible Relationships between Taurine Derivatives and Products of the Metabolism of Ketimines

      • Silvestro Duprè, Francesco Pinnen, Mario Fontana, Raffaella Coccia, Laura Pecci, Doriano Cavallini

      Pages 1-7

   2. The Inhibitory Effects of Taurine on Protein Phosphorylation: Comparison of Various Characteristics of the Taurine-Affected Phosphoproteins Present in Rat Retina, Brain and Heart

      • John B. Lombardini

      Pages 9-17

   3. Effect of Photolytically Generated Riboflavin Radicals and Oxygen on Hypotaurine Antioxidant Free Radical Scavenging Activity

      • Terrence R. Green, Jack H. Fellman

      Pages 19-29

   4. Taurine Protects against Oxidant-Induced Lung Injury: Possible Mechanism(s) of Action

      • Georgia Schuller-Levis, Michael R. Quinn, Charles Wright, Eunkyue Park

      Pages 31-39

   5. Sulphur Amino Acids and the Metabolic Response to Cytokines

      • R. F. Grimble

      Pages 41-49

   6. Expression and Regulation of the Taurine Transporter in Cultured Cell Lines of Human Origin

      • Vadivel Ganapathy, Frederick H. Leibach

      Pages 51-57

   7. Dietary Taurine Requirement of Cats is Determined by Microbial Degradation of Taurine in the Gut

      • James G. Morris, Quinton R. Rogers, Seungwook W. Kim, Robert C. Backus

      Pages 59-70

   8. Reactivity of Taurine with Aldehydes and its Physiological Role

      • Mizuho Ogasawara, Tomomi Nakamura, Ikuo Koyama, Masami Nemoto, Tsuguchika Yoshida

      Pages 71-78

3. Taurine and the Liver

   1. Hepatic Regulation of Cysteine Utilization for Taurine Synthesis

      • M. H. Stipanuk, P. J. Bagley, Y.-C. Hou, D. L. Bella, M. F. Banks, L. L. Hirschberger

      Pages 79-89

   2. Immunohistochemical Localization of Taurine-Conjugated Bile Acids in the Liver of Mouse, Rat, Monkey and Human

      • W. G. Ding, I. Tooyama, H. Kimura, K. Kuriyama

      Pages 91-98

   3. Effects of Taurine on Microsomal Enzyme Activities Involved in Liver Lipid Metabolism of Wistar Rats

      • Alfredo Cantafora, Chong Chao Yan, Yun Sun, Roberta Masella

      Pages 99-110

4. Taurine and the Kidney

   1. Inhibitors of Anion Exchanger Activity Reduce Sodium Chloride-Dependent Taurine Transport by Brush Border Vesicles

      • Russell W. Chesney, Andrea M. Budreau

      Pages 111-120

   2. Expression of Taurine Transporter and its Regulation by Diet in Xenopus laevis Oocytes Following Injection of Rat Kidney Cortex mRNA

      • Xiaobin Han, Russell W. Chesney

      Pages 121-130

   3. Regulation of Taurine Transport by External Taurine Concentration and Medium Osmolality in Renal Tubular Cells in Culture

      • Deborah P. Jones, Bin Jiang, Russell W. Chesney

      Pages 131-138

   4. Role of Taurine in the Kidney: Osmoregulatory Taurine Accumulation in Renal Medulla

      • Takeshi Nakanishi, Yoshihiro Takamitsu, Minoru Sugita

      Pages 139-148

   5. Taurine and Experimental Kidney Disease

      • Howard Trachtman, John A. Sturman

      Pages 149-157

   6. Protecting effect of Taurine against Hypoxic Cell Damage in Renal Tubular Cells Cultured in Different Transplant Preservation Solutions

      • Peter Wingenfeld, Stefan Strübind, Ute Gehrmann, Thomas Minor, Wolf Isselhard, Dietrich Michalk

      Pages 159-169

5. Taurine in Muscle and the Cardiovascular System

   1. Mechanisms Underlying Physiological and Pharmacological Actions of Taurine on Myocardial Calcium Transport

      • Stephen W. Schaffer, Cherry Ballard, Junichi Azuma

      Pages 171-180

   2. Cardioprotective Actions of Taurine against Intracellular and Extracellular Calcium-Induced Effects

      • Hiroyasu Satoh

      Pages 181-196

Taurine, or 2-aminoethane sulfonic acid, has long been known to be the major organic product formed from the breakdown of the sulfur-containing amino acids, methionine and cysteine. It is excreted as such in the urine or as bile acid conjugates in the bile. Research over the last 25 years, however, has uncovered an amazing variety of phenomena involving taurine. Despite the fact that the mechanism of action of taurine in some of these phenomena remains to be elucidated, it is clear that taurine is of far more physiological relevance than being the mere metabolic debris of sulfur amino acid catabolism. It also has numerous pharmacological actions that are beginning to be developed, as exemplified by some of the studies reported in this volume. This volume reports the proceedings of the latest of a series of international symposia, continuing on from the initial meeting held in Tucson, Arizona, in 1975. The latest symposium was the first to be held in Germany, in Cologne from August 29 through September 1, 1993. It continued the multidisciplinary approach that has been the norm for taurine symposia. We hope the publication of the proceedings will stimulate further investigations on this simple but fascinating compound.

• Alanin
• Amino acid
• Calcium
• Diabetes
• Diabetes mellitus
• Lipid
• Phosphor
• Riboflavin
• Transport
• biochemistry
• enzymes
• metabolism
• proteins
• surgery
• tissue

• College of Medicine, University of Arizona, Tucson, USA

  Ryan J. Huxtable

• University of Cologne, Cologne, Germany

  Dietrich Michalk

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