Dioxins and Health

1. Front Matter

   Pages i-xxii

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2. Overview

   • Thomas Webster, Barry Commoner

   Pages 1-50

3. Risk Assessments of Dioxinlike Compounds

   • Ellen K. Silbergeld, Peter L. deFur

   Pages 51-78

4. Environmental Sources, Distribution, and Fate of Polychlorinated Dibenzodioxins, Dibenzofurans, and Related Organochlorines

   • Douglas R. Zook, Christoffer Rappe

   Pages 79-113

5. Dioxins in Food

   • James R. Startin

   Pages 115-137

6. Toxicology of Dioxins and Related Chemicals

   • Michael J. DeVito, Linda S. Birnbaum

   Pages 139-162

7. Pharmacokinetics of Dioxins and Related Chemicals

   • James R. Olson

   Pages 163-197

8. Immunotoxicology of Dioxins and Related Chemicals

   • Nancy I. Kerkvliet

   Pages 199-225

9. Dose—Response Effects of Dioxins

   • Angelika M. Tritscher, George C. Clark, George W. Lucier

   Pages 227-247

10. Dioxins, Dibenzofurans, PCBs and Colonial, Fish-Eating Water Birds

    • John P. Giesy, James P. Ludwig, Donald E. Tillitt

    Pages 249-307

11. Developmental and Reproductive Toxicity of Dioxins and Other Ah Receptor Agonists

    • H. Michael Theobald, Richard E. Peterson

    Pages 309-346

12. Aquatic Toxicity of Dioxins and Related Chemicals

    • Mary K. Walker, Richard E. Peterson

    Pages 347-387

13. Dioxins and Mammalian Carcinogenesis

    • James Huff

    Pages 389-407

14. Neurochemical and Behavioral Sequelae of Exposure to Dioxins and PCBs

    • Richard F. Seegal, Susan L. Schantz

    Pages 409-447

15. Exposure Assessment

    • Arnold Schecter

    Pages 449-485

16. Human Health Effects of Polychlorinated Biphenyls

    • William J. Nicholson, Philip J. Landrigan

    Pages 487-524

17. Cancer Epidemiology

    • Lennart Hardell, Mikael Eriksson, Olav Axelson, Shelia Hoar Zahm

    Pages 525-547

18. Reproductive Epidemiology of Dioxins

    • Anne Sweeney

    Pages 549-585

19. Chemical, Environmental, and Health Aspects of the Seveso, Italy, Accident

    • Pier Alberto Bertazzi, Alessandro di Domenico

    Pages 587-632

20. The Yusho Rice Oil Poisoning Incident

    • Yoshito Masuda

    Pages 633-659

This book originated in a series of cross-disciplinary conversations in the years 1984-1990 between the editor, who is a physician-researcher involved in clinical and laboratory research, and a dioxin toxicologist. During the years in which the conversations took place, an extraordinary amount of new scientific literature was published related to dioxins, defined for purposes of this text as the chlorinated dibenzo-p-dioxins, dibenzofurans, polychlorinated biphe­ nyls (PCB's) and other compounds that are structurally and toxicologically similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7 ,8-TCDD), the most extensively studied and most toxic of this group of chemicals. Dioxins also began to interest not only chemists and toxicologists, but also specialists from diverse disciplines such as wildlife and environmental science, immunology, neuroscience,public health, epidemiology, med­ icine, government, law, sociology, and journalism. Specialists from such varied disciplines, while familiar with their own literature, frequently did not have time to follow the dioxin literature outside their specialty area. In addition, each specialty had unique knowledge, methods, and perspectives. Cross­ disciplinary conversation was necessary, but all too frequently, specialists from the various disciplines did not speak the same language, resulting in misunderstanding.

• Dioxin
• Furan
• biochemistry
• toxicity
• toxicology
• ecotoxicology

• Department of Preventive Medicine, University of New York Health Science Center-Syracuse, Binghamton, USA

  Arnold Schecter

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