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Modern Vaccinology

  • Book
  • © 1994

Overview

Editors:
  1. Edouard Kurstak

    1. University of Montreal, Montreal, Canada
      World Health Organization, Geneva, Switzerland

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-ix
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  2. Editor’s Introduction

    1. Modern Vaccinology: Progress Towards the Global Control of Infectious Diseases

      • Edouard Kurstak
      Pages 1-9

  3. New Concepts in Vaccines Development and Immune Response

    1. Front Matter

      Pages 11-11
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    2. Vaccination with Polynucleotides: A Novel Means of Generating Immunity

      • Jeffrey B. Ulmer, John J. Donnelly, Margaret A. Liu
      Pages 13-23

    3. Development of Vaccines by Grafting Microbial Epitopes in Immunoglobulins

      • Constantin A. Bona
      Pages 25-40

    4. Conventional and New Generation Combined Vaccines

      • Francis E. André, William J. Stanbury, Dirk E. Teuwen
      Pages 41-54

    5. Progress in the Development of Multivalent Oral Vaccines Based on Live Attenuated Salmonella

      • Steven N. Chatfield, Gordon Dougan, Mark Roberts
      Pages 55-86

    6. Potentiation of Vaccines Through Effective Adjuvant Formulations and Manipulation of the Immune Response

      • H. P. A. Hughes, L. A. Babiuk
      Pages 87-118

  4. Recombinant Vaccines and Multivalent Immunogens

    1. Front Matter

      Pages 119-119
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    2. Recent Advances in Recombinant Vaccines for Viral and Parasitic Diseases

      • John A. Tine, Jill Taylor, Enzo Paoletti
      Pages 121-151

    3. Hepatitis B Virus Recombinant Vaccines: Achievement and Progress

      • F. Tron
      Pages 153-167

    4. Recombinant Hepatitis B Surface Antigen as Carrier of Human Immunodeficiency Virus (HIV) Epitopes: Towards a Dual Immunogenic Vaccine

      • K. Schlienger, M. Mancini, P. Tiollais, M.-L. Michel
      Pages 169-179

    5. Genetically Engineered Human Immunodeficiency Virus Type 1 (HIV-1) Vaccines

      • Benjamin Rovinski, Michel Klein
      Pages 181-212

    6. Rotavirus Vaccine Development

      • Timo Vesikari, Albert Z. Kapikian
      Pages 213-229

    7. Progress in the Development of Recombinant Vaccines Against Dengue and Other Arthropod-Borne Flaviviruses

      • Robert Putnak
      Pages 231-252

    8. Expressed Antigens of Hantaviruses as Potential Vaccines for Hemorrhagic Fever with Renal Syndrome

      • Connie S. Schmaljohn, Joel M. Dalrymple, David McClain
      Pages 253-263

    9. Development of Recombinant Measles Vaccines

      • Jill Taylor, Enzo Paoletti
      Pages 265-281

    10. Development of Subunit Paramyxoviridae Vaccines

      • M. Ewasyshyn, Michel Klein
      Pages 283-301

    11. Rabies Recombinant Vaccines: Development and Field Application

      • P.-P. Pastoret, B. Brochier, D. Boulanger, G. Chappuis, M. P. Kieny
      Pages 303-318

    12. The New Generation of Recombinant Pertussis Vaccines

      • Sheena Loosmore, Gavin Zealey, Michel Klein
      Pages 319-340
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Keywords

About this book

The recent developments in modern vaccinology are mainly based on: (i) cloning of microbial genes into recombinant vectors containing genetic information for expression of desired neutralizing immunogens; (ii) alternatives of attenuated vectors with deleted genes permitting the insertion of several foreign genes expressing antigens exposed to the host immune system during the abortive replication of such vectors; (iii) combined vaccines with the aim to protect against many diseases with a limited number of administrations; (iv) evidence demonstrating the ability of animals to respond serologically to DNA injections considered as a potential method of vaccination; (v) the possibility to manipulate the immune system with new and improved immunomodulators enhancing the immune response; and (vi) new microcarrier systems for particular immunogens or immunomodulators delivery, either in a single dose or sustained release, and presentation to the immune system for a relevant response. New vaccines being developed are mainly based on viral, bacterial or other vectors modified with genetic engineering technology, to possess and express desired antigens for vaccination against single or multiple infections. Existing combined vaccines like diphtheria, tetanus, pertussis (DTP) are also experimented with new additional components like recombinant hepatitis B virus surface antigen, inactivated poliovirus, and Haemophilus inJluenzae type b immunogens, in order to produce multivalent vaccines. Such types of vaccines permitting the reduction of multiple medical visits is of particular interest to pediatric immuni­ zation programs, and would benefit especially the developing countries assuring better vaccine compliance with immunization schedules.

Editors and Affiliations

  • University of Montreal, Montreal, Canada

    Edouard Kurstak

  • World Health Organization, Geneva, Switzerland

    Edouard Kurstak

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