Standardization of Epidemiologic Studies of Host Susceptibility

1. Front Matter

   Pages i-xii

   PDF

2. Epidemiologic Standards for Diamond

   1. Preventing Diabetes — A Health Paradigm for the Next Century: Perspectives from the International Diabetes Federation (IDF)

      • Shigeaki Baba

      Pages 1-2

   2. The Contribution of DIAMOND and Multinational Studies to Epidemiological Research

      • Lewis H. Kuller

      Pages 3-6

   3. Beyond Insulin-Dependent Diabetes Mellitus Registries: Capture-Recapture Approaches for Monitoring Incidence

      • Ronald E. LaPorte, Daniel McCarty, Eugene Tull, Ingrid Libman, Masato Matsushima

      Pages 7-12

   4. Epidemiology of IDDM in Childhood in the Baltic Sea Region

      • Jaakko Tuomilehto, Toomas Podar, Bela Adojaan, Irina Kalits, Eva Tuomilehto-Wolf, Marjatta Karvonen et al.

      Pages 13-25

   5. Standards for IDDM Epidemiology in Asia

      • Naoko Tajima, Masato Matsushima

      Pages 27-33

3. Familial IDDM Epidemiology

   1. Standards for Family History Data Collection and Analyses for the WHO DIAMOND Project

      • Maria T. Tenconi

      Pages 35-41

   2. Siberian IDDM Register and the Collection of Standardized Family History Information

      • Evgene V. Shubnikov, Lada A. Kalashnikova

      Pages 43-45

   3. The Epidemiology of Familial Insulin-Dependent Diabetes Mellitus (IDDM) in Hungary

      • Gyula Soltész, Hungarian Childhood Diabetes Epidemiology Study Group

      Pages 47-52

   4. The IDDM Registry in the Province of Turin (Italy): Preliminary Data of the Familial Study

      • Graziella Bruno, Mauro Giorio, Gianfranco Pagano

      Pages 53-56

   5. The Risk of Insulin-Dependent Diabetes in Offspring of Parents with Insulin-Dependent Diabetes

      • Toomas Podar, Jaakko Tuomilehto, Eva Tuomilehto-Wolf, Ronald E. LaPorte, Janice S. Dorman

      Pages 57-67

   6. Differential HLA Contribution from Fathers Versus Mothers to IDDM Susceptibility

      • L. Leigh Field

      Pages 69-75

   7. HLA-DR3 and DR4 Allele Segregation in IDDM Families and in Controls

      • Cristina Daielli, Renata Lorini, Miryam Martinetti, Luisella Cortona, Mariaclara Cuccia, Letizia Vitali et al.

      Pages 77-82

   8. Preliminary Results of HLA Serological Typing of Insulin-Dependent Diabetes Mellitus Families in Puerto Rico

      • Teresa Frazer de Llado, Ramiro Milan, Gladys Veray, Magalys Soto, Arthur Hupka, Peggy Bull et al.

      Pages 83-88

4. Methods for Epidemiologic Studies of Host Susceptibility

   1. Case-Control Molecular Epidemiology Studies: Standards for the WHO DIAMOND Project

      • Janice S. Dorman, Mirjana Kocova, Leslie A. O’Leary, Mary Kaye Kramer, Massimo Trucco

      Pages 89-99

   2. Genetic Determinants of IDDM Incidence: An International Study of HLA Haplotypes in Multiplex Parent — Child Families

      • Eva Tuomilehto-Wolf, Jaakko Tuomilehto

      Pages 101-110

   3. Challenges in the Genetic Epidemiology of Insulin-Dependent Diabetes Mellitus

      • Anders Green

      Pages 111-115

   4. Molecular Studies of Genetic Distance and Admixture

      • Robert E. Ferrell

      Pages 117-124

   5. Immune Markers in Population Surveys and Family Studies

      • Bernhard O. Boehm, Werner A. Scherbaum

      Pages 125-133

   6. Geographic Differences in Antibodies to Glutamic Acid Decarboxylase in Insulin-Dependent Diabetes Mellitus

      • Paul Zimmet, Ian R. Mackay, Merrill Rowley, William Knowles, Susan W. Serjeantson

      Pages 135-143

The incidence of insulin-dependent diabetes mellitus (100M) varies dramatically across racial groups and countries, with annual age-adjusted rates of approximately 40/100,000 per year in Finland, but only 0.51100,000 per year in China. Although reasons for these marked geographic differences are unknown, it is likely that genetic variations across populations play a m~or role. To determine the contribution of genetic factors to the global patterns of 100M incidence, international comparative studies are now being undertaken as part of the WHO Multinational Project for Childhood Oiabetes, known as the DIAMOND Project. It is, therefore, necessary to develop and implement epidemiologic standards for these investigations which can be applied across populations. This will ensure that comparable data are obtained in all countries, and that relevant scientific questions can be properly addressed. The development of standards for molecular epidemiologic studies of 100M is the of the NATO Advanced Research Workshop. During this meeting at the objective University of Pittsburgh, scientists from across the world convened to discuss issues relating to the standardization of: 1. the collection of family history data to assess the risk of 100M in first degree relatives, 2. case-control molecular epidemiology studies of 100M susceptibility, 3. HLA family studies, 4. laboratory methods and ONA technology transfer for genetic marker evaluations.

• Diabetes
• World Health Organization
• development
• epidemiological
• epidemiology
• molecular epidemiology

• Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA

  Janice S. Dorman

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