Targeting of Drugs 4

1. Front Matter

   Pages i-viii

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2. Drug Targeting with Glycoproteins and Other Peptide Carriers: An Overview

   • Dirk K. F. Meijer

   Pages 1-30

3. Sugar Specific Delivery of Drugs, Oligonucleotides and Genes

   • M. Monsigny, A.-C. Roche, P. Midoux, R. Mayer

   Pages 31-50

4. The Use of MSH Derivatives for Targeting to Melanomas

   • David R. Bard, C. Graham Knight, E. Phillip Wraight, J. Van Beeumen, B. Deveese, F. Jacquemotte

   Pages 51-57

5. The Immunogenicity of Recombinant Proteins and of “Magic Bullets” Represents the Main Obstacle for the Effective In Vivo Targeting of Biologic Response Modifiers (BRMs)

   • A. H. Sehon

   Pages 59-65

6. Targeting of Drugs to Tumors: The Use of the Plasminogen Activator Inhibitor as a Ligand

   • Jerzy Jankun

   Pages 67-79

7. Advances in Diagnosis and Treatment of Neoplasia Using Radioactive Monoclonal Antibodies

   • Anthony Maraveyas, Agamemnon A. Epenetos

   Pages 81-90

8. Targeting Transcription Factors to Inhibit Selectively Gene Expression in Particular Cell Types

   • A. C. Allison, E. M. Eugui

   Pages 91-100

9. Design, Biological Properties and Delivery of Antisense Oligonucleotides

   • Jack S. Cohen

   Pages 101-111

10. Liposomes In Vivo: Control of Behaviour

    • Gregory Gregoriadis

    Pages 113-118

11. Passive Targeting of Anthracyclines Entrapped in Long-Circulating(Stealth) Liposomes in the Treatment of Cancer

    • T. M. Allen

    Pages 119-128

12. Liposomal Drug Delivery: Possibilities for Manipulation

    • G. Storm, I. A. J. M. Bakker-Woudenberg, M. C. Woodle, G. Blume, U. K. Nassander, M. H. Vingerhoeds et al.

    Pages 129-138

13. Polysialic Acids: In Vivo Properties and Possible Uses in Drug Delivery

    • Brenda McCormack, Gregory Gregoriadis

    Pages 139-145

14. Red Blood Cells as Carriers of Drugs Against Retroviruses

    • Mauro Magnani, Luigia Rossi, Laura Chiarantini, Alessandra Fraternale, Anna Casabianca

    Pages 147-152

15. Nanoparticles for the Delivery of Peptides and Proteins

    • P. Couvreur, F. Puisieux

    Pages 153-159

16. New Poly(Methylidene Malonate 2.1.2) Nanoparticles: Recent Developments

    • P. Breton, D. Roy, L. Marchal-Heussler, C. Seguin, P. Couvreur, F. Lescure

    Pages 161-172

17. Oral Uptake and Translocation of Nanoparticles: A Real but Useful Phenomenon?

    • A. T. Florence, A. M. Hillery, N. Hussain, P. U. Jani

    Pages 173-181

18. Particulate Systems for Site Specific Drug Delivery

    • S. S. Davis, L. Illum

    Pages 183-194

19. Back Matter

    Pages 195-207

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The NATO Advanced Studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in Cape Sounion, Greece, in which the present and the future of this important area of research in drug delivery is discussed in great depth. Previous ASIs of the series dealt with drug carriers of natural and synthetic origin, their interaction with the biological milieu, ways by which the latter influences such interaction, strategies by which milieu interference curtailing the function of drug carriers is circumvented and, more recently, with the application of drug carriers for the delivery of peptides and proteins. The present book contains the of the 7th NATO ASI "Targeting of Drugs: Advances in System Constructs", proceedings held in Cape Sounion during 24 June -5 July 1993. As the title implies, the book deals with a variety of approaches to carrier design or modification that contribute to optimal carrier function. to Mrs Concha Perring for her assistance with the We express our appreciation organization of the ASI. We thank Dr. G. Deliconstantinos who, as chairperson of the Local Committee, contributed to the success of the Institute. The ASI was held under the sponsorship of NATO Scientific Affairs Division and co-sponsored and generously financed by SmithKline Beecham Pharmaceuticals (King of Prussia). Financial assistance was also provided by Liposome Technology Inc. (Menlo Park), Vestar Inc. (San Dimas) and Zeneka (Macclesfield).

• Expression
• Nucleotide
• drug delivery
• gene expression
• protein
• proteins
• transcription

• Centre for Drug Delivery Research, The School of Pharmacy, University of London, London, England, UK

  Gregory Gregoriadis, Brenda McCormack

• SmithKline Beecham Pharmaceuticals, King of Prussia, USA

  George Poste

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