Diet and Cancer

1. Front Matter

   Pages i-xiv

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2. Use of Vitamins A and D in Chemoprevention and Therapy of Cancer: Control of Nuclear Receptor Expression and Function

   • R. M. Niles

   Pages 1-15

3. Vitamin A Chemoprevention of Lung Cancer

   • Carrie A. Redlich, Ariette M. Van Bennekum, Joel A. Wirth, William S. Blaner, Darryl Carter, Lynn T. Tanoue et al.

   Pages 17-29

4. Human Cervical Cancer

   • Richard L. Eckert, Chapla Agarwal, Joan R. Hembree, Chee K. Choo, Nywana Sizemore, Sheila Andreatta van Leyen et al.

   Pages 31-44

5. Role of Apoptosis in the Growth Inhibitory Effects of Vitamin D in MCF-7 Cells

   • JoEllen Welsh, Maura Simboli-Campbell, Carmen J. Narvaez, Martin Tenniswood

   Pages 45-52

6. Vitamin D and Prostate Cancer

   • David Feldman, Roman J. Skowronski, Donna M. Peehl

   Pages 53-63

7. Choline and Hepatocarcinogenesis in the Rat

   • Steven H. Zeisel, Kerry-Ann da Costa, Craig D. Albright, Ok-Ho Shin

   Pages 65-74

8. Dietary Effects on Gene Expression in Mammary Tumorigenesis

   • Polly R. Etkind

   Pages 75-83

9. Effect of Dietary Fatty Acids on Gene Expression in Breast Cells

   • Z. Ronai, J. Tillotson, L. Cohen

   Pages 85-95

10. Lipotrope Deficiency and Persistent Changes in DNA Methylation

    • Judith K. Christman

    Pages 97-106

11. Methionine Deprivation Regulates the Translation of Functionally-Distinct c-Myc Proteins

    • Stephen R. Hann

    Pages 107-116

12. Progressive Loss of Sensitivity to Growth Control by Retinoic Acid and Transforming Growth Factor-Beta at Late Stages of Human Papillomavirus Type 16-Initiated Transformation of Human Keratinocytes

    • Kim E. Creek, Gemma Geslani, Ayse Batova, Lucia Pirisi

    Pages 117-135

13. Short-Chain Fatty Acids and Molecular and Cellular Mechanisms of Colonic Cell Differentiation and Transformation

    • Leonard H. Augenlicht, Anna Velcich, Barbara G. Heerdt

    Pages 137-148

14. Fish Oil and Cell Proliferation Kinetics in a Mammary Carcinoma Tumor Model

    • Nawfal W. Istfan, Jennifer Wan, Zhi-Yi Chen

    Pages 149-156

15. Abstracts

    • Andrew Yen, Megan Williams, Joseph D. Platko, Channing Der, Mark Hisaka, Alexander M. Feigin et al.

    Pages 157-218

16. Back Matter

    Pages 219-222

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The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Differentiation. " A general overview on vitamins A and D emphasized that A and D, in addition to their established roles in vision, reproduction, and bone mineral homeostasis, may play significant roles in regulating cell function. Vitamin A metabolites, trans-retinoic acid and 9-cis-retinoic acid, regulate growth and differentiation. Furthermore, vitamin A­ deprived animals were more susceptible to both spontaneous and carcinogen-induced tumors. Epidemiological studies showed a correlation between low A intake and higher incidences of certain types of human cancers. Conversely, all-trans retinoic acid is useful in treatment and control of certain types of cancer. Physiologically, Vitamin D is converted to the active form, l ,25-dihydroxyvitamin D (VD). VD regulates hormone production and secretion, myocardial contractility, vascu­ 3 3 3 lar tone, and growth inhibition and differentiation.

• Carcinom
• Colon
• DNA
• Interferon
• Nutrition
• Translation
• Vitamin A
• Vitamin D
• cancer
• cancer prevention
• gene expression

• USA

  American Institute for Cancer Research

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