Overview
- Editors:
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American Institute for Cancer Research
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USA
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Table of contents (14 chapters)
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- Carrie A. Redlich, Ariette M. Van Bennekum, Joel A. Wirth, William S. Blaner, Darryl Carter, Lynn T. Tanoue et al.
Pages 17-29
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- Richard L. Eckert, Chapla Agarwal, Joan R. Hembree, Chee K. Choo, Nywana Sizemore, Sheila Andreatta van Leyen et al.
Pages 31-44
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- JoEllen Welsh, Maura Simboli-Campbell, Carmen J. Narvaez, Martin Tenniswood
Pages 45-52
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- David Feldman, Roman J. Skowronski, Donna M. Peehl
Pages 53-63
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- Steven H. Zeisel, Kerry-Ann da Costa, Craig D. Albright, Ok-Ho Shin
Pages 65-74
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- Z. Ronai, J. Tillotson, L. Cohen
Pages 85-95
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- Kim E. Creek, Gemma Geslani, Ayse Batova, Lucia Pirisi
Pages 117-135
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- Leonard H. Augenlicht, Anna Velcich, Barbara G. Heerdt
Pages 137-148
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- Nawfal W. Istfan, Jennifer Wan, Zhi-Yi Chen
Pages 149-156
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- Andrew Yen, Megan Williams, Joseph D. Platko, Channing Der, Mark Hisaka, Alexander M. Feigin et al.
Pages 157-218
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Back Matter
Pages 219-222
About this book
The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Differentiation. " A general overview on vitamins A and D emphasized that A and D, in addition to their established roles in vision, reproduction, and bone mineral homeostasis, may play significant roles in regulating cell function. Vitamin A metabolites, trans-retinoic acid and 9-cis-retinoic acid, regulate growth and differentiation. Furthermore, vitamin A deprived animals were more susceptible to both spontaneous and carcinogen-induced tumors. Epidemiological studies showed a correlation between low A intake and higher incidences of certain types of human cancers. Conversely, all-trans retinoic acid is useful in treatment and control of certain types of cancer. Physiologically, Vitamin D is converted to the active form, l ,25-dihydroxyvitamin D (VD). VD regulates hormone production and secretion, myocardial contractility, vascu 3 3 3 lar tone, and growth inhibition and differentiation.
