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Sensory Nerves and Neuropeptides in Gastroenterology

From Basic Science to Clinical Perspectives

  • Book
  • © 1991

Overview

Editors:
  1. Marcello Costa

    1. Flinders University of South Australia, Adelaide, Australia

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  2. Calogero Surrenti

    1. University of Florence, Florence, Italy

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  3. Sergio Gorini

    1. Fondazione Internazionale Menarini, Florence, Italy

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  4. Carlo Alberto Maggi

    1. A. Menarini Pharmaceuticals, Florence, Italy

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  5. Alberto Meli

    1. A. Menarini Pharmaceuticals, Florence, Italy

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 298)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Capsaicin as a Tool for Studying Sensory Neuron Functions

    • Peter Holzer
    Pages 3-16

  3. Chemical Coding of Neurons in the Gastrointestinal Tract

    • M. Costa, S. Brookes, P. Steele, J. Vickers
    Pages 17-27

  4. Occurrence and Distribution of Substance P- and CGRP-Containing Nerve Fibers in Gastric Mucosa: Species Differences

    • F. Sundler, E. Ekblad, R. Håkanson
    Pages 29-37

  5. Tachykinin and Calcitonin Gene-Related Peptide Immunoreactivities and Mrnas in the Mammalian Enteric Nervous System and Sensory Ganglia

    • Catia Sternini
    Pages 39-51

  6. Peptides and their Receptors on Afferent Neurons to the Upper Gastrointestinal Tract

    • G. J. Dockray, E. R. Forster, S. M. Louis
    Pages 53-62

  7. Activation of Sensory Nerves by Kinins: Pharmacologic Tools for Studying Kinin Receptors

    • D. Regoli, N.-E. Rhaleb, N. Rouissi, C. Tousignant, D. Jukic, C. Drapeau
    Pages 63-74

  8. Evolutionary Aspects in the Peripheral Peptidergic Signals: CRF-Like Peptides and Modulation of G.I. Functions

    • Giovanna Improta
    Pages 75-83

  9. Gastric and Jejunal Ultrastructure in Capsaicin-Treated Rats with and without Experimental Ulcer

    • Carl J. Pfeiffer, Stefano Evangelista
    Pages 85-96

  10. Afferent Nerve-Mediated Control of Gastric Mucosal Blood Flow and Protection

    • Peter Holzer
    Pages 97-108

  11. Vagal Afferent Innervation and Regulation of Gastric Function

    • Helen E. Raybould, Peter Holzer, Gerard Thiefin, Helge H. Holzer, Masashi Yoneda, Yvette F. Tache
    Pages 109-127

  12. Decrease of Duodenal Calcitonin Gene-Related Peptide- and Substance P-Like Immunoreactivity in Rat Duodenal Ulcers

    • Daniela Renzi, Stefano Evangelista, Paola Mantellini, Calogero Surrenti
    Pages 129-135

  13. Opioid-Sensitive Peripheral Neuronal Activity in the Modulation of Gastric Mucosal Injury

    • J. V. Esplugues, B. J. R. Whittle
    Pages 137-146

  14. Relationship between Sensory Neuropeptides and other Local Vasoactive Mediators in Modulating Gastric Mucosal Integrity

    • Brendan J. R. Whittle
    Pages 147-156

  15. Effect of Substance P and Related Neurokinins on Gastric Acid Secretion

    • G. Coruzzi, M. Adami, G. Bertaccini
    Pages 157-165

  16. Effect of Calcitonin Gene-Related Peptide (CGRP) on Aspirin- and Ethanol-Induced Injury in the Rat Stomach

    • Irmgard Theresia Lippe
    Pages 167-174

  17. Visceral Pain: Pathophysiology and Clinical Aspects

    • Paolo Procacci, Marco Maresca, Riccardo Maria Cersosimo
    Pages 175-181

  18. Central and Peripheral Actions of Calcitonin Gene-Related Peptide on Gastric Secretory and Motor Function

    • Yvette Taché, Helen Raybould, Jen Yu Wei
    Pages 183-198

  19. Sensory Nerves of the Intestines: Role in Control of Pyloric Region of Dogs

    • Gervais Tougas, Hans-D. Allescher, John Dent, Edwin E. Daniel
    Pages 199-211

  20. Vasoactive Intestinal Polypeptide (VIP) and the Specific Motor Response to Capsaicin of the Human Isolated Ileum

    • Carlo Alberto Maggi, Sandro Giuliani, Paolo Santicioli, Riccardo Patacchini, Elvar Theodorsson, Damiano Turini et al.
    Pages 213-217
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Keywords

About this book

In the past 15 years much evidence has accumulated which indicates the paramount importance of sensory nerves in reg­ ulating functions of the gastrointestinal tract. In parallel, the attention of researchers in this field has been increas­ ingly attracted to the role played by neuropeptides in the normal and diseased gut. Basic research on the peculiar properties of capsaicin, the pungent ingredient from plants of the genus Capsicum, has allowed the gap between these two areas of research to be bridged. Sincethen, the study of gut afferents and neuropeptides has become more and more interconnected and recognized as a major avenue to understand­ ing the pathophysiology of various human diseases. It is widely recognized that a certain subset of primary afferents synthesize, store and release neuropeptides (such as tachykin­ nins and calcitonin gene-related peptide) from their central and peripheral endings, the latter being widely distributed in the alimentary canal and related organs (liver, pancreas). The First International Meeting on Sensory Nerves and Neuropeptides in Gastroenterology, held in Florence from December 4-5, 1989, sponsored and organized by Fondazione Internazionale Menarini, aimed to focus the current status of research in this field. The contributions presented at the meeting and in this book delineate a suggestive scenario in which sensory nerves of the gut, and the multiple messages they carry through the release of neuropeptides, are to be considered as a major target for the development of new drugs potentially useful in a number of diseases of the gastro­ intestinal tract.

Editors and Affiliations

  • Flinders University of South Australia, Adelaide, Australia

    Marcello Costa

  • University of Florence, Florence, Italy

    Calogero Surrenti

  • Fondazione Internazionale Menarini, Florence, Italy

    Sergio Gorini

  • A. Menarini Pharmaceuticals, Florence, Italy

    Carlo Alberto Maggi, Alberto Meli

Bibliographic Information

  • Book Title: Sensory Nerves and Neuropeptides in Gastroenterology

  • Book Subtitle: From Basic Science to Clinical Perspectives

  • Editors: Marcello Costa, Calogero Surrenti, Sergio Gorini, Carlo Alberto Maggi, Alberto Meli

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4899-0744-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Hardcover ISBN: 978-0-306-43911-7Published: 30 June 1991

  • Softcover ISBN: 978-1-4899-0746-2Published: 04 June 2013

  • eBook ISBN: 978-1-4899-0744-8Published: 21 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 308

  • Topics: Gastroenterology, Hepatology, Pharmacology/Toxicology, Neurosciences

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