Giardia and Giardiasis

1. Front Matter

   Pages i-xxiv

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2. Structure and Physiology

   1. Front Matter

      Pages 1-1

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   2. Structure of the Trophozoite and Cyst

      • Dennis E. Feely, Stanley L. Erlandsen, David G. Chase

      Pages 3-31

   3. Trophozoite Motility and the Mechanism of Attachment

      • Stanley L. Erlandsen, Dennis E. Feely

      Pages 33-63

   4. Metabolism of Trophozoites

      • Donald G. Lindmark, Edward L. Jarroll

      Pages 65-80

   5. Giardia Isozymes

      • Miriam A. Bertram, Patrick Muller, Ernest A. Meyer

      Pages 81-87

   6. Methods of Isolating Trophozoites and Cysts

      • Dennis E. Feely

      Pages 89-97

   7. In Vitro Cultivation of Giardia Trophozoites

      • Ernest A. Meyer, Simona Radulescu

      Pages 99-109

   8. The Role of Reducing Agents and the Physiology of Trophozoite Attachment

      • Frances D. Gillin

      Pages 111-130

   9. Models for Excystation

      • Ernest A. Meyer, Frank W. Schaefer III

      Pages 131-144

3. Giardiasis

   1. Front Matter

      Pages 145-145

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   2. Symptomatology, Diagnosis, and Treatment

      • Martin S. Wolfe

      Pages 147-161

   3. Changes in the Small Intestinal Mucosa in Giardiasis

      • J. Gillon, Anne Ferguson

      Pages 163-183

   4. Cellular and Humoral Immunity in Giardiasis

      • I. C. Roberts-Thomson, R. F. Anders

      Pages 185-200

   5. Human Immune Responses to Giardia lamblia

      • Phillip D. Smith

      Pages 201-218

   6. Antigenicity of Giardia lamblia and the Current Status of Serologic Diagnosis of Giardiasis

      • Govinda S. Visvesvara, George R. Healy

      Pages 219-232

   7. Animal Models for Giardiasis

      • Ernest A. Meyer, Stanley L. Erlandsen, Simona Radulescu

      Pages 233-240

4. Epidemiology

   1. Front Matter

      Pages 241-241

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   2. Waterborne Outbreaks of Giardiasis

      • Gunther F. Craun

      Pages 243-261

   3. Detection of Giardia Cysts in Drinking Water

      • Walter Jakubowski

      Pages 263-286

The intestinal protozoan Giardia was first described over 300 years ago in 1681 by Leeuwenhoek, from his own stools. In his description of Giardia, he noted the size, movement, and morphology of the organism, and associated its presence with the diarrheic nature of his stools and his dietary habits. This truly remarkable account contains the first description of Giardia in morphologic, pathogenic, and epidemiologic terms. Our knowledge of the organisms in the genus Giardia has advanced tremendously in the past two decades. With the advent of new tech­ nologies, including techniques in electron microscopy, biochemistry, immunochemistry, tissue culture, and physiology, a tidal wave of information has appeared on the organization and function of this parasitic protozoan and its interaction with its host. The purpose of this book is to celebrate the tricentennial discovery of Giardia by Leeuwenhoek by presenting the above-mentioned advances in our knowledge of Giardia and giardiasis. In the first section of this book, the dominant theme is the biology of the organism and the correlation of structure-function relationships.

• antigen
• biochemistry
• biology
• electron microscopy
• epidemiology
• immune response
• immunity
• metabolism
• microscopy
• parasite
• pathogenesis
• physiology
• protozoa
• tissue
• water

• Department of Anatomy, School of Medicine, University of Minnesota, Minneapolis, USA

  Stanley L. Erlandsen

• Department of Microbiology and Immunology, Oregon Health Sciences University, Portland, USA

  Ernest A. Meyer

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