Opioid Analgesics

1. Front Matter

   Pages i-xv

   PDF

2. Introduction

   • Alan F. Casy, Robert T. Parfitt

   Pages 1-8

3. 4,5-Epoxymorphinans

   • Alan F. Casy, Robert T. Parfitt

   Pages 9-104

4. Morphinans

   • Alan F. Casy, Robert T. Parfitt

   Pages 105-151

5. Benzomorphans

   • Alan F. Casy, Robert T. Parfitt

   Pages 153-214

6. Arylmorphans and Related Compounds

   • Alan F. Casy, Robert T. Parfitt

   Pages 215-227

7. Pethidine and Related 4-Phenylpiperidine Analgesics

   • Alan F. Casy, Robert T. Parfitt

   Pages 229-249

8. Further Analgesics Based on Piperidine and Related Azacycloalkanes: Prodines, Promedols, Profadol, and Their Derivatives

   • Alan F. Casy, Robert T. Parfitt

   Pages 251-285

9. Fentanyl and the 4-Anilinopiperidine Group of Analgesics

   • Alan F. Casy, Robert T. Parfitt

   Pages 287-301

10. Methadone and Related 3,3-Diphenylpropylamines

    • Alan F. Casy, Robert T. Parfitt

    Pages 303-332

11. Enkephalins, Endorphins, and Other Opioid Peptides

    • Alan F. Casy, Robert T. Parfitt

    Pages 333-384

12. Miscellaneous Groups of Analgesics

    • Alan F. Casy, Robert T. Parfitt

    Pages 385-403

13. Antagonists, Dualists, and Kappa Agonists

    • Alan F. Casy, Robert T. Parfitt

    Pages 405-444

14. Opioid Receptors: Facts and Speculations

    • Alan F. Casy, Robert T. Parfitt

    Pages 445-502

15. Back Matter

    Pages 503-518

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The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal­ gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono­ logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

• analgesics
• biochemistry
• chemistry
• opioid
• pharmacology
• receptor
• research

• University of Bath, Bath, UK

  Alan F. Casy, Robert T. Parfitt

• Canberra College of Advanced Education, Belconnen, Australia

  Robert T. Parfitt

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