Mechanisms of Lymphocyte Activation and Immune Regulation VI

1. Front Matter

   Pages i-ix

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2. Cell Cycle and Signaling Pathways in Apoptosis

   1. Apoptosis/Programmed Cell Death

      • Sudhir Gupta

      Pages 1-9

   2. Apoptosis and Its Regulation

      • J. John Cohen

      Pages 11-20

   3. Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages

      • Robert A. Schlegel, Melissa Callahan, Stephen Krahling, Deepti Pradhan, Patrick Williamson

      Pages 21-28

   4. Cytotoxic Lymphocyte Killing Enters the Ice Age

      • Seamus J. Martin, Gustavo P. Amarante-Mendes, Douglas R. Green

      Pages 29-37

   5. Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231

      • Steven J. Chmura, Edwardine Nodzenski, Mary A. Crane, Subbulakshmi Virudachalam, Dennis E. Hallahan, Ralph R. Weichselbaum et al.

      Pages 39-55

   6. Cell Cycle Control of T Cell Apoptosis Induced by Activation Through the T Cell Antigen Receptor

      • N. Jan Chalupny, Liqing Zhu, Xue-zhong Yu, Claudio Anasetti

      Pages 57-67

   7. Role of Antibody Signaling in Inducing Tumor Dormancy

      • Jonathan W. Uhr, Radu Marches, Emil Racila, Thomas F. Tucker, Robert Hsueh, Nancy E. Street et al.

      Pages 69-74

3. Apoptosis-Regulating Genes

   1. Regulation of Lymphoid Apoptosis by Bcl-2 and Bcl-xL

      • Gabriel Nuñez, Ramon Merino, Philip L. Simonian, Didier A. M. Grillot

      Pages 75-82

   2. The Epstein—Barr Virus Gene BHRF1, a Homologue of the Cellular Oncogene Bcl-2, Inhibits Apoptosis Induced by Gamma Radiation and Chemotherapeutic Drugs

      • N. J. McCarthy, S. A. Hazlewood, D. S. Huen, A. B. Rickinson, G. T. Williams

      Pages 83-97

   3. Structure—Function Analysis of Bcl-2 Family Proteins

      • John C. Reed, Hongbin Zha, Christine Aime-Sempe, Shinichi Takayama, Hong-Gang Wang

      Pages 99-112

   4. Role of Ice-Proteases in Apoptosis

      • Vishva M. Dixit

      Pages 113-117

   5. Fas-Mediated Apoptosis

      • Shigekazu Nagata

      Pages 119-124

   6. Fas Splicing Variants and their Effect on Apoptosis

      • Giovina Ruberti, Isabella Cascino, Giuliana Papoff, Adriana Eramo

      Pages 125-134

   7. The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses

      • David H. Lynch

      Pages 135-138

4. Apoptosis in B Cells

   1. Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes

      • John Gordon, Christopher D. Gregory, Gillian Grafton, John D. Pound

      Pages 139-144

   2. Regulation of B Cell Apoptosis

      • Robert F. Ashman, David Peckham, Laura L. Stunz

      Pages 145-154

   3. Apoptotic Cell Death in the Chicken Bursa of Fabricius

      • Karen A. Jacobsen, Eustache Paramithiotis, Don L. Ewert, Michael J. H. Ratcliffe

      Pages 155-165

   4. Generation and Regulation of B Cell Autoreactivity Arising in the Periphery

      • Philip Kuo, Daniel Michael, Boaz Tadmor, Betty Diamond

      Pages 167-176

   5. Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes

      • Thomas L. Rothstein, Linda C. Foote, Thomas J. Schneider, Gavin M. Fischer, Bruce A. Jacobson, David H. Lynch et al.

      Pages 177-189

Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

• T cell
• Thymus
• apoptosis
• diseases
• insects
• lymphocytes
• macrophages
• programmed cell death
• proteins
• virus

`This book is a valuable addition to the literature.'
Quarterly Review of Biology, March 1998

• University of California, Irvine, Irvine, USA

  Sudhir Gupta

• University of Colorado Health Sciences Center, Denver, USA

  J. John Cohen

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