Platelet-Activating Factor and Related Lipid Mediators 2

1. Front Matter

   Pages i-xiv

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2. The Continuing Biochemical Challenge of PAF and Closely Related Lipid Mediators

   • Donald J. Hanahan

   Pages 1-3

3. Biosynthesis of Platelet-Activating Factor and Enzyme Inhibitors

   • Fred Snyder, Veronica Fitzgerald, Merle L. Blank

   Pages 5-10

4. Inhibitors of Arachidonate Metabolism and Effects on PAF Production

   • James D. Winkler, Chiu-Mei Sung, Lisa A. Marshall, Floyd H. Chilton

   Pages 11-15

5. Production of Platelet-Activating Factor by Brain Microvascular Endothelial Cells

   • Kei Satoh, Masayuki Koyama, Hidemi Yoshida, Shigeru Takamatsu

   Pages 17-20

6. PAF-Synthesizing Enzymes in Neural Cells during Differentiation and in Gerbil Brain during Ischemia

   • Ermelinda Francescangeli, Louis Freysz, Gianfrancesco Goracci

   Pages 21-27

7. Platelet-Activating Factor Production in the Stimulated Macrophages is Enhanced by the Cyclooxygenase Inhibitors

   • Masateru Yamada, Masako Watanabe, Suetsugu Mue, Kazuo Ohuchi

   Pages 29-32

8. The Role of Peroxisomes in Ether Lipid Synthesis

   • H. van den Bosch, E. C. J. M. de Vet, A. W. M. Zomer

   Pages 33-40

9. Platelet-Activating Factor Synthesis and Its Role in Salivary Glands

   • T. Dohi, K. Itadani, H. Yamaki, Y. Akagawa, K. Morita, S. Kitayama

   Pages 41-44

10. Physiological Action of PAF in Yeast Saccharomyces Cerevisiae

    • Reiko Nakayama, Cheolwon Yun, Hisanori Tamaki, Kunihiko Saito, Hidehiko Kumagai

    Pages 45-50

11. Free Radical-Induced Oxidation of Glycerophosphocholine Lipids and Formation of Biologically Active Products

    • Robert C. Murphy

    Pages 51-58

12. A Discovery Trip to Compounds with PAF-Like Activity

    • Constantinos A. Demopoulos, Smaragdi Antonopoulou

    Pages 59-63

13. Biologically Active Lipids from S. Scombrus

    • John Rementzis, Smaragdi Antonopoulou, Dimitris Argyropoulos, Constantinos A. Demopoulos

    Pages 65-72

14. Purification and Partial Characterization of the PAF Antagonist from the Saliva of the Leech Hirudo Medicinalis

    • Miriam Orevi, Amiram Eldor, Maria-Elisabeth Gödeke, Meir Rigbi

    Pages 73-77

15. Platelet-Activating Factor Receptor

    • Takao Shimizu, Hiroyuki Mutoh, Shigeaki Kato

    Pages 79-84

16. Transcriptional Regulation of Platelet-Activating Factor Receptor Gene Expression in Leukocytes

    • Jong-Hwei S. Pang, Haw-Harn Yang, Lee-Young Chau

    Pages 85-87

17. PAF Receptor Anchors Streptococcus Pneumoniae to Activated Human Endothelial Cells

    • Diana R. Cundell, Craig Gerard, Ilona Idanpaan-Heikkila, Elaine I. Tuomanen, Norma P. Gerard

    Pages 89-94

18. Up-Regulation of the Intracellular Ca2+ Signaling and mRNA Expression of Platelet-Activating Factor Receptor by Estradiol in Human Uterine Endometrial Cells

    • Sayuri Sato, Kazuhiko Kume, Tomoko Takan, Hiroyuki Mutoh, Yuji Taketani, Takao Shimizu

    Pages 95-100

19. Functional Role of Platelet-Activating Factor Receptor in Secretory Response in Adrenal Chromaffin Cells

    • T. Dohi, K. Morita, Y. Imai, S. Kitayama

    Pages 101-105

20. Functional and Structural Features of Plasma Platelet-Activating Factor Acetylhydrolase

    • Larry W. Tjoelker, Chris Eberhardt, Cheryl Wilder, Greg Dietsch, Hai Le Trong, Lawrence S. Cousens et al.

    Pages 107-111

In the last decade, research on platelet-activating factor (PAF) has expanded exponentially. Previous conferences on PAF in Paris, 1983, and the subsequent conferences in Gatlinburg, Ten­ nessee, Tokyo, Snowbird, Utah, and Berlin, at three-yearly intervals, have chronicled the devel­ opments in the field ofPAF. This volume records the proceedings of the Fifth International Con­ gress on PAF and Related Lipid Mediators, held at the Free University Medical Hospital Ben­ jamin Franklin in Berlin, from September 12-16, 1995. We are very much indebted to Free Uni­ versity Berlin for providing tremendous facilities and financial support. It was a great pleasure to have positive and generous input from the German Science Council (DFG), Bonn, Germany, and British·Biotech, Oxford, United Kingdom. Their support was crucial in making the congress a scientific success. Twenty other organizations provided additional financial support, for which we extend our deepest appreciation. The editors would like to thank all of those who participated in this congress and the authors for their contributions. The organization and planning of the Berlin Congress were carried out by an organizing committee. We gratefully acknowledge the support and assistance of the organizing commit­ tee members, especially Renate Nigam and Renate Roux for their untiring efforts to make the congress successful. Many colleagues also supported the congress with dedication, hard work, and expert input. We are grateful to them. We also wish to acknowledge the support of G. Sravan Kumar and Louis Kock for their efforts in producing this volume.

• Lipid
• cell signalling
• enzymes
• gene expression
• tissue

• Free University Berlin, Berlin, Germany

  Santosh Nigam, Gert Kunkel

• University of Utah, Salt Lake City, USA

  Stephen M. Prescott

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