Control of Metabolic Processes

1. Front Matter

   Pages i-xiii

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2. Prologue

   1. Front Matter

      Pages 1-1

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   2. What Should a Theory of Metabolic Control Offer to the Experimenter?

      • Daniel E. Atkinson

      Pages 3-27

3. General Aspects of Control Theory

   1. Front Matter

      Pages 29-29

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   2. The Nature and Role of Theory in Metabolic Control

      • Athel Cornish-Bowden

      Pages 31-40

   3. History and Original Thoughts on the Control Theoretic Approach

      • Joseph Higgins

      Pages 41-49

   4. Control Analysis: a Theory that Works

      • John W. Porteous

      Pages 51-67

   5. Biochemical Systems Theory: Alternative Views of Metabolic Control

      • Michael A. Savageau

      Pages 69-87

   6. Comparison of Accuracy of Alternative Models for Biochemical Pathways

      • Eberhard O. Voit

      Pages 89-100

   7. Modern Control Theories: a Consumers’ Test

      • Albert K. Groen, Hans V. Westerhoff

      Pages 101-118

4. Mathematical Aspects of Control Analysis

   1. Front Matter

      Pages 119-119

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   2. The Structural Approach to Metabolic Control Analysis I: Theoretical Aspects

      • Christine Reder

      Pages 121-127

   3. The Structural Approach to Metabolic Control Analysis II: Geometrical Aspects

      • Jean-Pierre Mazat, Christine Reder, T. Letellier

      Pages 129-138

   4. Control Coefficients and the Matrix Method

      • David A. Fell, Herbert M. Sauro, J. Rankin Small

      Pages 139-148

   5. Performance Indices in Metabolic Systems: a Criterion for Evaluating Effectiveness in Metabolic Regulation

      • Marta Cascante, Rafael Franco, Enric I. Canela

      Pages 149-156

   6. Practical Determination of Control Coefficients in Metabolic Pathways

      • Enric I. Canela, Marta Cascante, Rafael Franco

      Pages 157-169

5. Interconvertible Enzymes in Metabolic Control

   1. Front Matter

      Pages 171-171

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   2. Zero-order Ultrasensitivity in Interconvertible Enzyme Systems

      • Albert Goldbeter, Daniel E. Koshland Jr.

      Pages 173-182

   3. Metabolic Control by the Cyclic Cascade Mechanism: a Study of E. coli Glutamine Synthetase

      • P. Boon Chock, Sue Goo Rhee, Earl R. Stadtman

      Pages 183-194

   4. Properties Needed for the Enzymes of an Interconvertible Cascade to Generate a Highly Sensitive Response

      • María Luz Cárdenas, Athel Cornish-Bowden

      Pages 195-207

THIS BOOK collects together papers given at a NATO Advanced Research Workshop held at Il Ciocco (Lucca), Italy, from the 9th to the 15th April, 1989. It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of analysing the kinetics of multi-enzyme pathways developed over the past two decades have come to be widely discussed or applied experimentally. Many biochemists remain sceptical that the new methods offer a real advance (except in complexity) over the landmark discoveries of the 1950s and 1960s relating to inhibition of enzymes at branch-points by the end products of metabolic pathways, and the interpretation of allosteric effects and cooperativity. Even those who have become convinced that the classical ideas provide only the starting point for understanding metabolic control have been by no means unanimous in their assess­ ment of the direction in which one should advance. In this book we have tried to include all of the current points of view, including the view that the classical theories tell us all that we need to know. We have not seen it as our role as editors to paper over the cracks that exist and to pretend that we can speak to the world with one voice.

• Amino acid
• Glutamin
• Glycogen
• Nucleotide
• Purine
• Termination
• biosynthesis
• enzymes
• gene expression
• genes
• metabolic control
• metabolism
• diabetes

• Center for Biochemistry and Molecular Biology—CNRS, Marseille, France

  Athel Cornish-Bowden, María Luz Cárdenas

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