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Chemical Carcinogenesis

Models and Mechanisms

  • Book
  • © 1988

Overview

Editors:
  1. Francesco Feo

    1. University of Sassari, Sassari, Italy

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  2. Paolo Pani

    1. University of Cagliari, Cagliari, Italy

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  3. Amedeo Columbano

    1. University of Cagliari, Cagliari, Italy

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  4. Renato Garcea

    1. University of Sassari, Sassari, Italy

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Table of contents (71 chapters)

  1. Front Matter

    Pages i-xv
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  2. Xenobiotics: Metabolism and Interaction with Cellular Macromolecules

    1. Front Matter

      Pages 1-1
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    2. Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors

      • Harry V. Gelboin, Frank J. Gonzalez, Sang S. Park, Junji Sagara, Narayana Battula
      Pages 3-15

    3. Cytochromes P-450 as Determinants of Susceptibility to Carcinogenesis by Aromatic Amines and Nitroaromatic Hydrocarbons

      • Fred F. Kadlubar, F. Peter Guengerich, Mary Ann Butler, K. Barry Delclos
      Pages 17-23

    4. Species-Dependent Differences in the Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Cells in Culture

      • William M. Baird, Teresa A. Smolarek, Said M. Sebti, Donna Pruess-Schwartz
      Pages 25-36

    5. Complex Metabolic Activation Pathways of Polycyclic Aromatic Hydrocarbons: 3-Hydroxy-trans-7,8-Dihydroxy-7,8-Dihydrobenzo[a]Pyrene as a Proximate Mutagen of 3-Hydroxybenzo[a]Pyrene

      • Hansruedi Glatt, Paul C. Hirom, Charles A. Kirkby, Odartey Ribeiro, Albrecht Seidel, Franz Oesch
      Pages 37-44

    6. Carcinogenicity of Methyl Halides: Current Problems Concerning Chloromethane

      • Hermann M. Bolt, Hans Peter, Rainer Jäger
      Pages 45-51

    7. Relationship Between Structure and Mutagenic/Carcinogenic Activity of Short Chain Aliphatic Halocompounds: A Collaborative Project

      • Giorgio Cantelli-Forti, G. L. Biagi, P. A. Borea, G. Bronzetti, M. C. Guerra, P. Hrelia et al.
      Pages 53-65

    8. Enzymatic Detoxication of Tumorigenic Bay-Region Diol-Epoxides of Polycyclic Aromatic Hydrocarbons by Conjugation with Glutathione

      • Bengt Jernström, Iain G. C. Robertson, Bengt Mannervik, Lennart Dock
      Pages 67-73

    9. Antigenotoxic and Anticarcinogenic Effects of Thiols. In Vitro Inhibition of the Mutagenicity of Drug Nitrosation Products and Protection of Rat Liver ADP-Ribosyl Transferase Activity

      • Silvio De Flora, Carmelo F. Cesarone, Carlo Bennicelli, Anna Camoirano, Domizio Serra, Monia Bagnasco et al.
      Pages 75-86

    10. Relationships between NADPH Content and Benzo(a)pyrene Metabolism in Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Human Fibroblasts

      • Rosa Pascale, Lucia Daino, Maria E. Ruggiu, Maria G. Vannini, Renato Garcea, Serenella Frassetto et al.
      Pages 87-92

    11. Comparison of the Covalent Binding of Various Chloroethanes with Nucleic Acids

      • Giorgio Prodi, Annamaria Colacci, Sandro Grilli, Giovanna Lattanzi, Mario Mazzullo, Paola Turina
      Pages 93-102

    12. In Situ Detection of Hepatic AF-DNA Adduct Formation During Continuous Feeding of 0.02% Acetylaminofluorene and in Enzyme-Altered Foci Induced by Foyr Different Protocols

      • Henrik S. Huitfeldt, Henry C. Pitot, John M. Hunt, Jeffrey Baron, Miriam C. Poirier
      Pages 103-109

    13. Interaction of Activated N-Nitrosamines with DNA

      • Jamie R. Milligan, Laura Catz-Biro, Samim Hirani-Hojatti, Michael C. Archer
      Pages 111-117

    14. Antibodies Specific for DNA Components Modified by Chemical Carcinogens and Their Binding Efficiency to DNA Modified in Vivo and in Vitro with the Corresponding Carcinogens

      • Erik Kriek, Frederik J. van Schooten, Michel J. X. Hillebrand, Maarten C. Welling
      Pages 119-128

    15. Liver DNA Damage by Chemical Carcinogens: Role of Thyroid Hormones

      • Marco Presta, Marco Rusnati, Jeanette A. M. Maier, Giovanni Ragnotti
      Pages 129-135

    16. Activation of Urinary Bladder Carcinogens within the Target Organ

      • Luisa Airoldi, Marina Bonfanti, Cinzia Magagnotti, Roberto Fanelli
      Pages 137-142

    17. Lipid Peroxidation and Bioactivation of Halogenated Hydrocarbons in Rat Liver Mitochondria During Experimental Siderosis

      • Aldo Tomasi, Emanuele Albano, Barbara Botti, Francesco P. Corongiu, M. Assunta Dessì, Anna Iannone et al.
      Pages 143-151

    18. Lipid Peroxidation, Protein Thiols, Calcium Homeostasis and Imbalance of Antioxidant Systems in Bromobenzene Induced Liver Damage

      • Alessandro F. Casini, Emilia Maellaro, Alfonso Pompella, Marco Ferrali, Mario Comporti
      Pages 153-163

  3. Developmental Stages of Carcinogenesis

    1. Front Matter

      Pages 165-165
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Keywords

About this book

About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino­ genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.

Editors and Affiliations

  • University of Sassari, Sassari, Italy

    Francesco Feo, Renato Garcea

  • University of Cagliari, Cagliari, Italy

    Paolo Pani, Amedeo Columbano

Bibliographic Information

  • Book Title: Chemical Carcinogenesis

  • Book Subtitle: Models and Mechanisms

  • Editors: Francesco Feo, Paolo Pani, Amedeo Columbano, Renato Garcea

  • DOI: https://doi.org/10.1007/978-1-4757-9640-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1988

  • Softcover ISBN: 978-1-4757-9642-1Published: 18 July 2013

  • eBook ISBN: 978-1-4757-9640-7Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XV, 679

  • Topics: Life Sciences, general

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