Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular

1. Front Matter

   Pages i-xiv

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2. Eicosanoids and Related Analytes

   1. Front Matter

      Pages 1-1

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   2. The Use of HPLC in Studies of the Stereoselective Metabolism of Prostaglandin D2

      • Clive Robinson

      Pages 3-13

   3. Analysis of Eicosanoids by GC-MS/MS

      • J. C. Frölich, K.-H. Marx, H. Bippi, J. Fauler, B. Rosenkranz, U. Förstermann

      Pages 15-21

   4. Quantitative Determination of Several Prostaglandins and Thromboxane B2 in the Isolated Perfused Rat Brain

      • Claudia Weber, Klaus Belsner, Barbara Osikowska-Evers, Inge Luhmann, Michael Höller

      Pages 23-27

   5. Analytical Methods for [3H]-Enisoprost, an Anti-Secretory PGE1 Analogue, and its Metabolites

      • L. A. Allan, A. J. Hawkins, J. Firth, R. D. Brownsill, J. A. Steiner, C. W. Vose

      Pages 29-35

   6. Identification of a New Metabolite of Leukotriene B4 by RP-HPLC and GC-MS Analysis

      • Joachim Fauler, Karl-Heinz Marx, Volkhard Kaever

      Pages 37-41

   7. Radioimmunoassay of Eicosanoids: Its Application in the Development of Anti-Inflammatory and Analgesic Drugs

      • Frank Carey, Duncan Haworth, Robert A. Forder

      Pages 43-50

3. Notes and Comments Relating to Eicosanoids and Related Analytes

   1. Front Matter

      Pages 51-51

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   2. Developing Methods for a Thromboxane Synthetase Inhibitor and a Prostacyclin Analogue in Biological Fluids: Problems and Some Solutions

      • M. V. Doig, R. A. Clare

      Pages 53-55

   3. The Stereochemical Analysis of Monohydroxyfatty Acids, Particularly 12-Hydroxy-5,8,10,14-Eicosatetraenoic Acid

      • P. M. Woollard

      Pages 57-63

4. Anti-Inflammatory Drugs

   1. Front Matter

      Pages 65-65

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   2. Analysis of the Actions of Anti-Inflammatory Drugs, with Particular Reference to Effects on Interleukins and Leucocytes

      • K. D. Rainsford

      Pages 67-76

   3. Immunoassay of Beclomethasone 17,21-Dipropionate and Metabolites

      • W. N. Jenner, D. J. Kirkham

      Pages 77-86

   4. HPLC Analysis of Anti-Inflammatory Agents (Non-Steroidal and Steroidal)

      • J. C. McElnay

      Pages 87-95

   5. Analytical Approaches Adopted during the Development of Flurbiprofen

      • A. Bye, W. Adams, D. Kaiser

      Pages 97-105

   6. The Assay of Diclofenac and Metabolites: A Review

      • P. H. Degen

      Pages 107-114

   7. Enantiomeric Analysis of 2-Phenylpropionic Acid NSAID’s in Biological Fluids by HPLC

      • A. J. Hutt, J. Caldwell

      Pages 115-125

5. Notes and Comments Relating to Anti-Inflammatory Drugs

   1. Front Matter

      Pages 127-127

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   2. The Determination of Suprofen in Biological Fluids

      • C. J. Dyde, M. F. Barkworth, K. D. Rehm

      Pages 129-132

vi as did non-appreciation that % values for bought-in solutions (notably ammonia) may be on a weight basis, not made evident by the manufacturer. Notwithstanding the shortcomings or lateness of some texts, authors are thanked for compiling them amidst other pressures. Elsevier and the American Chemical Society are also thanked, for Figures now reproduced with source acknowledgement. This Editor has generally respected authors' phrasing, whilst shuddering when the term 'incubate' is encountered in a 0° context. He remains a 'diehard' in certain respects, notably in favouring 'M' rather than 'mol/I', and a wt./ml basis for drug concentrations in test samples; he regards 'mmol/l' as a fatuous fashion. Concerning infelicitous abbreviations, a distinction is made between electron­ capture (detector context; 'ECD') and electrochemical ('EC', never 'ECD'); the hallowed GC term 'FID' means free induction decay to NMR practi tione:ts, who may pardon the term 'Fid' as introduced editorially. The convention for ,0C' throughout the book is '0'. Undefined but well-known abbreviations include GC, HPLC and TLC. MS (mass spectrometry), NPD (nitrogen-phosphorus detector), tr (retention time) and RIA (radioimmunoassay) are usually defined in the article concerned, as are the HPLC modes NP (normal-/straight­ phase) and RP (reversed-phase; C-lS and ODS are synonymous), and i.s.

• Mass Spectrometry
• NMR
• drug
• nitrogen
• nuclear magnetic resonance (NMR)
• phase
• phosphorus
• research
• society
• spectrometry

• Guildford Academic Associates, Guildford, UK

  Eric Reid

• Hoechst UK, Milton Keynes, UK

  J. D. Robinson

• ICI Pharmaceuticals Division, Macclesfield, UK

  Ian D. Wilson

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