Antimicrobial Susceptibility Testing

1. Front Matter

   Pages i-xii

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2. Introduction

   1. Introduction

      • James A. Poupard, Lori R. Walsh, Bruce Kleger

      Pages 1-2

3. Current Methods

   1. The Evolution of Antimicrobial Susceptibility Testing Methods

      • James A. Poupard, Stephen F. Rittenhouse, Lori R. Walsh

      Pages 3-14

   2. Antimicrobial Susceptibility Tests: Testing Methods and Interpretive Problems

      • Patrick R. Murray

      Pages 15-25

   3. Clinician Utilization of Rapid Antibiotic Susceptibility Data: A Prospective Study

      • Franklin P. Koontz

      Pages 27-34

4. Contemporary Issues in Susceptibility Testing

   1. When We should be Testing, How often and what to Report

      • Raymond C. Bartlett

      Pages 35-60

   2. Areas of Recent Emphasis of the National Committee for Clinical Laboratory Standards Subcommittee on Antimicrobial Susceptibility Testing

      • James H. Jorgensen

      Pages 61-65

   3. Non-Traditional Approaches for Quality Control of Antimicrobial Susceptibility Tests

      • Janet Hindler

      Pages 67-85

   4. Applications of Medical Informatics in Antibiotic Therapy

      • R. Scott Evans, Stanley L. Pestotnik

      Pages 87-96

5. New and Developmental Methods

   1. Established Antimicrobial Susceptibility Testing Methods with a New Twist — Points to Consider and a Glimpse of the Future

      • Lori R. Walsh

      Pages 97-105

   2. Measures of Susceptibility from a Spiral Gradient of Drug Concentrations

      • Samuel Schalkowsky

      Pages 107-120

   3. Commercialization of Nucleic Acid Probe Technology: Current Status

      • James H. Godsey, Kurt M. Vanden Brink, Luke J. DiMichele, Laura A. Beninsig, W. Richard Peterson, David G. Sherman

      Pages 121-129

6. Rapidly Approaching Controversial Issues

   1. Is One Laboratory in Town Enough?

      • Joel E. Mortensen

      Pages 131-134

   2. The FDA Review Criteria for Assessment of Antimicrobial Susceptibility Devices — Too Much or Not Enough Regulation?

      • Karla M. Tomfohrde

      Pages 135-143

   3. The Evolution of Clinical Laboratory Regulation — A Primer for Universal Health Care

      • James E. Prier

      Pages 145-152

   4. Current Issues in Antimicrobial Susceptibility Testing

      • James A. Poupard, Lori R. Walsh

      Pages 153-156

7. Selected Manuscripts from Poster Presentations

   1. The Use of In-Vitro Kinetic Models in the Evaluation of β-Lactam/β-Lactamase Inhibitor Combinations

      • Christine E. Thorburn, Brian Slocombe

      Pages 157-162

   2. Prevalence of Ticarcillin/Clavulanic Acid-Resistant Enterobacteriacaeae in Nine Separate Medical Centers During the Years 1983, 1989, and 1991

      • Arthur L. Barry

      Pages 163-176

   3. Correlation of Minimum Inhibitory Concentration Results between the Vitek System and the Biomic System

      • Tammy L. Wolfram, C. Ross McFarland, James A. Poupard

      Pages 177-186

8. Back Matter

   Pages 187-191

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The papers assembled in this collection comprise a majority of the oral presentations as well as several poster presentations given at the 22nd Annual Symposium arranged by the Bastern Pennsylvania Branch of the American Society for MicrobioloS)'. The symposium would not be possible without the generous support of the many sponsors (see sponsor list) or without the concerted effort of a11 the Committee members. This Symposium series has evolved into an annual Bastern Pennsylvania Branch ASM event that attracts participants from a wide geographie area. It should be noted that one of the hallmarks of these symposia involves interaction between the presenters and those in attendance. Several authors have altered their by the participants. Therefore, the manuscript that manuscripts based on comments fo11ows should be viewed as a group effort of both the participants and presenters. J ames Poupard Lori Walsh Bruee Kleger ix CONTENTS 1 Introduction 1: CURRENT METHODS The Evolution of Antimicrobial Susceptibility Testing Methods . . . . . . . . . . . . . . . 3 James A. Poupard, Stephen F. Rittenhouse, and Lori R. Walsh Antimicrobial Susceptibility Tests: Testing Methods and Interpretive Problems. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Patrick R. Murray Clinician Utilization of Rapid Antibiotic Susceptibility Data: A Prospective Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Franklin P. Koontz SESSION 2: CONTEMPORARY ISSUES IN SUSCEPTIBILITY TESTING When We Should Be Testing, How Often and What to Report . . . . . . . . . . . . . . . 35 Raymond C. Bartlett Areas of Recent Emphasis of the National Committee for Clinical Laboratory Standards Subcommittee on Antimicrobial Susceptibility Testing . . . . . . . . . . . . . . . . .. . . . . . 61 James H. Jorgensen Non-Traditional Approaches for Quality Control of Antimicrobial Susceptibility Tests . . . . . . . . . . . . . . . . . . . . . . . . .

• antibiotic
• antibiotics
• antimicrobial
• assessment
• bacteria
• development
• drug
• evolution
• health
• health care
• research
• infectious diseases

• SmithKline Beecham Pharmaceuticals, King of Prussia, USA

  James A. Poupard

• Abington Memorial Hospital, Abington, USA

  Lori R. Walsh

• Pennsylvania Department of Health, Lionville, USA

  Bruce Kleger

Policies and ethics