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Angiogenesis

Molecular Biology, Clinical Aspects

  • Book
  • © 1994

Overview

Editors:
  1. Michael E. Maragoudakis

    1. University of Patras Medical School, Patras, Greece

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  2. Pietro M. Gullino

    1. University of Torino Medical School, Torino, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. Peter I. Lelkes

    1. University of Wisconsin Medical School, Milwaukee, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 263)

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Embryonic Development and Angiogenesis

    1. Embryology of the Endothelial Network: Is There an Hemangioblastic Anlage ?

      • Françoise Dieterlen-Lièvre, Dominique Luton, Luc Pardanaud
      Pages 1-8

    2. Cellular and Molecular Biology of Endothelial Cell Differentiation during Embryonic Development

      • Thomas J. Poole
      Pages 9-14

    3. Endothelial Cell Heterogeneity and Organ — Specificity

      • Peter I. Lelkes, Vangelis G. Manolopoulos, Dawn Chick, Brian R. Unsworth
      Pages 15-28

  3. Molecular Biology of Angiogenesis

    1. Inhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis

      • Peter J. Polverini
      Pages 29-37

    2. Human Basic Fibroblast Growth Factor: Structure-Function Relationship of an Angiogenic Molecule

      • Marco Presta, Marco Rusnati, Anna Gualandris, Patrizia Dell’Era, Chiara Urbinati, Daniela Coltrini et al.
      Pages 39-50

    3. Angiogenesis Models Identify Factors Which Regulate Endothelial Cell Differentiation

      • D. S. Grant, D. Morales, M. C. Cid, H. K. Kleinman
      Pages 51-60

    4. EMA-1, a Novel Endothelial Cell Surface Molecule That is Preferentially Expressed by Migrating Endothelial Cells

      • Hellmut G. Augustin-Voss, Bendicht U. Pauli
      Pages 61-65

    5. Early Response Genes in Endothelial Cells

      • Timothy Hla
      Pages 67-72

    6. P1GF: Placenta Derived Growth Factor

      • Domenico Maglione, Maria Graziella Persico
      Pages 73-80

    7. Expression of the M-Subunit of Laminin Correlates with Increased Cell Adhesion and Metastatic Propensity

      • Wheamei Jenq, Shi-Jun Wu, Nicholas A. Kefalides
      Pages 81-89

    8. The Proliferative Effect of Substance P on Capillary Endothelial Cells is Mediated by Nitric Oxide

      • M. Ziche, L. Morbidelli, L. Mantelli, E. Masini, F. Ledda, H. J. Granger et al.
      Pages 91-96

    9. Reactivation of Metalloproteinase-Inhibitor Complex by a Low Molecular Mass Angiogenic Factor

      • B. Mclaughlin, J. B. Weiss
      Pages 97-101

    10. Interactions between Oxidized Lipoprotein (a) [Lp(a)], Monocytes and Endothelial Cells

      • Mahmoud Ragab, Periasamy Selvaraj, Demetrios S. Sgoutas
      Pages 103-109

    11. Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins

      • Theodosia A. Kalfa, Mary E. Gerritsen, Effie C. Tsilibary
      Pages 111-118

    12. A Novel Laminin Domain Involved in Adhesion of Endothelial Cells

      • Aristidis Charonis, Nitsa Koliakos, George Koliakos, Gregg Fields, Lorrel Regger, Carrie Lynch et al.
      Pages 119-123

  4. Regulation of Angiogenesis

    1. Regulation of Angiogenesis: The Role of Protein Kinase, Nitric Oxide, Thrombin and Basement Membrane Synthesis

      • M. E. Maragoudakis, N. E. Tsopanoglou, G. C. Haralabopoulos, E. Sakkoula, E. Pipili-Synetos, E. Missirlis
      Pages 125-134

    2. Basement Membrane Laminin-Derived Peptide Sikvav Promotes Angiogenesis and Tumor Growth

      • Hynda K. Kleinman, Derrick S. Grant, Maura C. Kibbey
      Pages 135-141

    3. Release of Gangliosides in the Microenvironment and Angiogenic Response in Vivo

      • Pietro M. Gullino
      Pages 143-147

    4. Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis

      • Michael S. Pepper, Jean-Dominique Vassalli, Lelio Orci, Roberto Montesano
      Pages 149-170
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Keywords

About this book

Angiogenesis is a multistep process, which involves activation, proliferation and directed migration of endothelial cells to form new capillaries from existing vessels. Under physiological conditions, in the adult organisms angiogenesis is extremely slow, yet it can be activated for a limited time only in situations such as ovulation or wound healing. In a number of disease states, however, there is a derangement of angiogenesis, which can contribute to the pathology of these conditions. Hence, understanding the molecular biology of endothelial cell activation and differentiation and the mechanisms involved in the regulation of angiogenesis, could explain the derangement in disease states and also provide the basis for developing promoters or suppressors of angiogenesis for clinical applications. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis: Molecular Biology, Oinical Aspects" held in Rhodes, Greece, from June 16-27, 1993. This meeting was a comprehensive review of the various aspects of angiogenesis such as embryonic development, endothelial cell heterogeneity and tissue specificity, molecular biology of endothelial cell, mechanisms for the regulation of angiogenesis, disease states in which angiogenesis is involved and potential application of promoters or suppressors of angiogenesis. The presentations and discussions of the meeting provided an opportunity for investigators from many different areas of basic science and medicine to exchange information, evaluate the present status and provide future research directions in the field of angiogenesis.

Editors and Affiliations

  • University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  • University of Torino Medical School, Torino, Italy

    Pietro M. Gullino

  • University of Wisconsin Medical School, Milwaukee, USA

    Peter I. Lelkes

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