Skip to main content
SpringerLink
Log in

Prostate Cancer

Biology, Genetics, and the New Therapeutics

  • Book
  • © 2001

Overview

Editors:
  1. Leland W. K. Chung

    1. University of Virginia School of Medicine, Charlottesville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. William B. Isaacs

    1. The Johns Hopkins University School of Medicine, Baltimore, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Jonathan W. Simons

    1. The Johns Hopkins Hospital, Baltimore, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Cancer Research (CCR)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (29 chapters)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Building the Road to Defeat Prostate Cancer

      • W. Steven Ward
      Pages 3-10

  3. Cancer Genetics

    1. Front Matter

      Pages 11-11
      Download chapter PDF

    2. Hereditary Prostate Cancer

      • William B. Isaacs, Jianfeng Xu, Patrick C. Walsh
      Pages 13-28

    3. AR Gene Alterations in Prostate Cancer Progression

      • Tapio Visakorpi
      Pages 29-37

    4. Lethal Metastatic Human Prostate Cancer

      • G. Steven Bova, Kirk M. Chan-Tack, William W. LeCates
      Pages 39-60

    5. Tumor Suppressor Genes in Prostate Cancer

      • Robert Bookstein
      Pages 61-94

    6. Androgen Receptor Polymorphisms and Prostate Cancer Risk

      • Phillip G. Febbo, Philip W. Kantoff
      Pages 95-109

    7. The Genetic Epidemiology of Prostate Cancer

      • Ronald K. Ross, Juergen K. V. Reichardt, Sue Ann Ingles, Gerhard A. Coetzee
      Pages 111-121

    8. Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques

      • Junqi Qian, Robert B. Jenkins
      Pages 123-140

    9. Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN)

      • Paul H. Duray, David K. Ornstein, Cathy D. Vocke, Stephen M. Hewitt, Kristina A. Cole, John W. Gillespie et al.
      Pages 141-161

    10. Xenograft Models and the Molecular Biology of Human Prostate Cancer

      • Robert E. Reiter, Charles L. Sawyers
      Pages 163-174

    11. Comprehensive Analyses of Prostate Gene Expression

      • Peter S. Nelson
      Pages 175-189

  4. Cancer Biology

    1. Front Matter

      Pages 191-191
      Download chapter PDF

    2. The Role of the Nuclear Matrix and Cytoskeleton in Cancer

      • Robert H. Getzenberg
      Pages 193-206

    3. The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis

      • Jer-Tsong Hsieh
      Pages 207-218

    4. Ligand Dependent and Independent Activation of the Androgen Receptor

      • Gloria R. Mora, Donald J. Tindall
      Pages 219-239

    5. Tyrosine Kinases and Cellular Signaling in Prostate Cancer

      • Hsing-Jien Kung, Clifford G. Tepper, Ralph W. deVere White
      Pages 241-266

    6. Molecular Pathways Underlying Prostate Cancer Progression

      • Timothy C. Thompson, Terry L. Timme, Likun Li, Chengzen Ren, Alexei Goltsov, Salahaldin Tahir et al.
      Pages 267-277
Back to top

Keywords

About this book

This book embraces the wide field of prostate cancer genetics, biology, and therapy. It seems most appropriate to dedicate it to Donald S. Coffey, PhD, whose research vision is an inspiration to his colleagues and friends. Unraveling the secrets of prostate cancer is an intricate and sometimes frustrating process involving many researchers and many institutions. No one has seen through to the end of this road, and the list of researchers who have contributed to our understanding of the disease processes of prostate cancer is already a long one. But Donald Coffey stands out in his personal qualities as surely as in his roles as teacher and researcher. In the dedicatory article that begins this volume, Dr. Ward has spoken for all of us about Don Coffey's unique determination to build the road to defeat prostate cancer. This book is divided into three sections: Cancer Genetics, Cancer Biology, and Cancer Therapeutics. These sections, like the skill and knowledge of the contributors, overlap in many dimensions. The divisions between sections are somewhat arbitrary and have been made expressly for the convenience of the reader. The reader will find chapters in each section that illuminate aspects ofthe genetics, biology, and therapy of prostate cancer. Nothing better illustrates the breadth of the research being conducted today by these distinguished groups, who truly understand and appreciate the power of multi­ disciplinary and translational approaches to deciphering the intricacy of the object of this research.

Reviews

"...the editors have done a remarkable job in selecting the topics and compiling the various articles into a comprehensive and easily accessible volume. The chapters are concise and informative, covering highly innovative studies being conducted in the field of recent years...the complexity of prostate cancer biology is well represented in the book, and the resourceful information can benefit not only those who are interested in prostate biology, but also those researchers employing molecular and cellular approaches to solve other important biological questions." - Quarterly Review of Biology

"...a welcome addition to the literature...The main strength of this book is that experts from several disciplines have contributed their thoughts on recent advances in prostate cancer...I strongly recommend this book to researchers who study prostate cancer, whether at the bench or at the bedside, and to clinicians who treat patients with prostate cancer... the book covers our current knowledge of prostate cancer and its treatment and helps define the foundation for future directions." - New England Journal of Medicine

"Well researched and extensively referenced, the book provides a valuable source of information on the current state of understanding of the molecular biology of prostate cancer, and the treatment modalities in routine clinical practice." - ACP News

"Each chapter is presented in a way that provides all available knowledge on the subject and the book structure allows readers to use a single section or chapter according to their interests. All these characteristics make the book a valuable tool to general oncologists or urologists interested in updating their basic knowledge of prostate cancer." -Annals of Oncology

Editors and Affiliations

  • University of Virginia School of Medicine, Charlottesville, USA

    Leland W. K. Chung

  • The Johns Hopkins University School of Medicine, Baltimore, USA

    William B. Isaacs

  • The Johns Hopkins Hospital, Baltimore, USA

    Jonathan W. Simons

Bibliographic Information

  • Book Title: Prostate Cancer

  • Book Subtitle: Biology, Genetics, and the New Therapeutics

  • Editors: Leland W. K. Chung, William B. Isaacs, Jonathan W. Simons

  • Series Title: Contemporary Cancer Research

  • DOI: https://doi.org/10.1007/978-1-59259-009-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • eBook ISBN: 978-1-59259-009-4Published: 15 December 2000

  • Edition Number: 1

  • Number of Pages: XVIII, 531

  • Number of Illustrations: 58 b/w illustrations, 1 illustrations in colour

  • Topics: Urology

Publish with us

Policies and ethics

Back to top

Search

Navigation