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Membrane Dynamics and Domains

Subcellular Biochemistry

  • Book
  • © 2004

Overview

Editors:
  1. Peter J. Quinn

    1. Department of Life Sciences, King’s College London, London, UK

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Part of the book series: Subcellular Biochemistry (SCBI, volume 37)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Membrane Domain Structure

    1. Front Matter

      Pages 1-1
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    2. Membrane Receptor Mapping: The Membrane Topography of FcεRI Signaling

      • Janet M. Oliver, Janet R. Pfeiffer, Zurab Surviladze, Stanly L. Steinberg, Karin Leiderman, Margaret L. Sanders et al.
      Pages 3-34

    3. Rafts, Little Caves and Large Potholes: How Lipid Structure Interacts with Membrane Proteins to Create Functionally Diverse Membrane Environments

      • Roger Morris, Helen Cox, Enrico Mombelli, Peter J. Quinn
      Pages 35-118

  3. Membrane Domain Composition

    1. Front Matter

      Pages 119-119
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    2. Lipid Raft Proteins and Their Identification in T Lymphocytes

      • Bernd Wollscheid, Priska D. von Haller, Eugene Yi, Samuel Donohoe, Kelly Vaughn, Andrew Keller et al.
      Pages 121-152

    3. Lipid Composition of Membrane Domains

      • Kamen S. Koumanov, Claude Wolf, Peter J. Quinn
      Pages 153-163

  4. Creation of Membrane Microdomains

    1. Front Matter

      Pages 165-165
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    2. Sphingomyelin and Cholesterol: From Membrane Biophysics and Rafts to Potential Medical Applications

      • Yechezkel Barenholz
      Pages 167-215

    3. Membrane Targeting of Lipid Modified Signal Transduction Proteins

      • Marilyn D. Resh
      Pages 217-232

    4. Role of the Membrane Skeleton in Creation of Microdomains

      • Ken Ritchie, Akihiro Kusumi
      Pages 233-245

    5. Membrane/Cytoskeleton Communication

      • Karina F. Meiri
      Pages 247-282

  5. Regulation of Domain Formation

    1. Front Matter

      Pages 283-283
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    2. GPI-anchored Protein Cleavage in the Regulation of Transmembrane Signals

      • Frances J. Sharom, Galina Radeva
      Pages 285-315

    3. Membrane Lipid Homeostasis

      • Claude Wolf, Peter J. Quinn
      Pages 317-357

    4. Phospholipid Metabolism in Lung Surfactant

      • Ruud Veldhuizen, Fred Possmayer
      Pages 359-388

  6. Signal Transduction Processes

    1. Front Matter

      Pages 389-389
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    2. Membrane Targeting in Secretion

      • Michael Schrader
      Pages 391-421

  7. Domain Dynamics in Disease

    1. Front Matter

      Pages 423-423
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    2. Oxidative Stress, Caveolae and Caveolin-1

      • Marie-Odile Parat, Paul L. Fox
      Pages 425-441
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Keywords

About this book

The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif­ ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc­ tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main­ tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.

Editors and Affiliations

  • Department of Life Sciences, King’s College London, London, UK

    Peter J. Quinn

Bibliographic Information

  • Book Title: Membrane Dynamics and Domains

  • Book Subtitle: Subcellular Biochemistry

  • Editors: Peter J. Quinn

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/978-1-4757-5806-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-0-306-48425-4Published: 02 July 2004

  • Softcover ISBN: 978-1-4419-3447-5Published: 07 December 2010

  • eBook ISBN: 978-1-4757-5806-1Published: 29 June 2013

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: XVI, 499

  • Topics: Biochemistry, general, Oncology

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