Mechanisms of Lymphocyte Activation and Immune Regulation II

1. Front Matter

   Pages 1-10

   PDF

2. T Cell Receptors and T Cell Activation

   1. Front Matter

      Pages 11-11

      PDF

   2. A Model for T Cell Receptor and MHC/Peptide Interaction

      • Mark M. Davis, Pamela J. Bjorkman

      Pages 13-16

   3. Human T Cell Receptor γδ Structure

      • Michael B. Brenner, Frans Hochstenbach, Hamid Band, Christina Parker, Joanne McLean, Shingo Hata et al.

      Pages 17-19

   4. The Role of the Zeta Chain in the Expression, Structure and Function of the T Cell Receptor

      • Richard D. Klausner, Allan M. Weissman, Michal Baniyash, Juan S. Bonifacino, Lawrence E. Samelson

      Pages 21-24

   5. Use of Somatic Cell Mutants to Study the Signal Transduction Function of the T Cell Antigen Receptor

      • Mark A. Goldsmith, Linda K. Bockenstedt, Paul Dazin, Arthur Weiss

      Pages 25-33

   6. Changes in Early and Late Steps of T Cell Activation by WT31 MoAb

      • Sudhir Gupta, Makito Shimizu, Renu Batra, Bharathi Vayuvegula

      Pages 35-42

3. Interleukin 1 and Interleukin 2 Receptors

   1. Front Matter

      Pages 43-43

      PDF

   2. Interleukin-1 Induced T-Lymphocyte Proliferation and Its Relation to IL-1 Receptors

      • Charles A. Dinarello, Scott F. Orencole, Nerina Savage

      Pages 45-53

   3. Structure and Regulation of the Human IL-2 Receptor

      • Warner C. Greene, Ernst Böhnlein, Miriam Siekevitz, Dean W. Ballard, B. Robert Franza, John W. Lowenthal

      Pages 55-60

   4. Structure-Function Relationships for High and Low-Affinity Interleukin 2 Receptors

      • Richard J. Robb

      Pages 61-65

4. B Lymphocyte Development and B Cell Activation

   1. Front Matter

      Pages 67-67

      PDF

   2. Cellular and Molecular Requirements for B Lymphopoiesis

      • Jeffrey M. Gimble, Shin-Ichi Hayashi, Carolynn E. Pietrangeli, Grace Lee, Paul W. Kincade

      Pages 69-75

   3. Transcriptional Regulation of Immunoglobulin Heavy Chain and T-Cell Receptor Beta Chain Genes

      • Skye McDougall, Suzanne Eaton, Craig L. Peterson, Kathryn Calame

      Pages 77-86

   4. Precursor B Lymphocytes — Specific Monoclonal Antibodies and Genes

      • Fritz Melchers, Steven R. Bauer, Christoph Berger, Hajime Karasuyama, Akira Kudo, Antonius Rolink et al.

      Pages 87-93

   5. G-Protein Regulation of Polyphosphoinositide Breakdown in B Cells

      • G. G. B. Klaus, M. M. Harnett, K. P. Rigley

      Pages 95-100

   6. Signal Transduction via the B Cell Antigen Receptor: Involvement of a G Protein and Regulation of Signaling

      • Anthony L. DeFranco, Michael R. Gold

      Pages 101-112

   7. Voltage-Sensitive Ion Channels in Human B Lymphocytes

      • Jeffrey B. Sutro, Bharathi S. Vayuvegula, Sudhir Gupta, Michael D. Cahalan

      Pages 113-122

5. Interleukins and B Lymphocyte Activation

   1. Front Matter

      Pages 123-123

      PDF

   2. Interleukins 4 and 5: Mechanisms of Action

      • Eva Severinson, Hee-Bom Moon, Susanne Bergstedt-Lindqvist, Ulla Persson, Christoph Heusser, Janet Stavnezer

      Pages 125-133

The ac ti vati on of Iymphocytes by physiologie ligands has become a central area of study for immunologists. Furthermore, Iymphocytes offer many advantages for the study of general aspects of receptor-mediated cellular activation. For these reasons, research on the cellular and molecular aspects of the activation of Iymphocytes by antigens, antigen analogues, Iymphokines and other growth factors has expanded enormously in the last several years. Aseries of conferences, "The International Conferences on Lymphocyte Activation", has been initiated to meet the growing need for a forum for the discussion of the topics that are included within the area of Iymphocyte activation. This volume represents the proceedings of the Second International Conference on Lymphocyte Activation and Immune Regulation, held on February 18-20, 1988 at Newport Beach, California. The proceedings comprise four major sections. The first deals with the T cell receptors and T cell activation. It includes a model for the T cell receptor interaction with a complex of MHC plus antigen, structure of y c'i T cell receptor and their distinct isotypic forms, the role of zeta chain in the expression and structure of T cell receptors and its role in transmembrane signalling. The use of somatic cell mutants in the study of signal transduction function of the T cell antigen receptors and the early and late steps of signal transduction via a / ß T cell antigen receptors are discussed.

• T cell
• antibody
• antigen
• cytokine
• growth factor
• immunoglobulin
• lymphocytes
• physiology

• Division of Basic and Clinical Immunology, University of California, Irvine, Irvine, USA

  Sudhir Gupta

• National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, USA

  William E. Paul

Policies and ethics